Mucopolysaccharidosis is a lysosomal storage disorder, caused due to deficiency of enzymes required for the breakdown Mucopolysaccharides. These undegraded Mucopolysaccharides accumulate in various tissues and cause characteristic features like neurological deficit, impaired motor function, developmental delay, hearing loss, behavioral problems, corneal clouding, glaucoma, respiratory distress,...

Mucopolysaccharides were extracted by Pronase diges tion from two types of rat tumor tissues: MC sarcoma in duced in Donryu rats by s.c. injection of methylcholanthrene and a solid tumor developed by s.c. transplantation of AH-109A cells into the animals. The mucopolysaccharides were fractionated by anion-exchange chromatography and characterized by chemical analysis, electrophoresis, infrared ...

Myocardial necrosis was produced in rats by administering isoproterenol, and the increase in hexosamine-containing materials in the injured myocardium was investigated. Total hexosamine, galactosamine, neutral sugars, and uronic acids were determined on various fractions isolated from the hearts. Mucopolysaccharides were precipitated as the cetyl pyridinium chloride complex and fractionated acc...

Acid mucopolysaccharides of human plasma have been observed ( 1 ) to vary as do acute phase reactants, i.e., to increase nonspecifically in any inflammatory state. The euglobulin fraction itself with which the acid mucopolysaccharides were associated increased also in such circumstances. On later comparing levels of acid mucopolysaccharides in samples of serum and plasma drawn simultaneously, i...

BACKGROUND At least 20 inborn errors of metabolism may cause hydrops fetalis. Most of these are lysosomal storage diseases. The study proposes a diagnostic flowchart for prenatal diagnosis of non-immune hydrops fetalis. METHODS This study contains a series of 75 non-immune hydrops fetalis pregnancies. Mucopolysaccharides, oligosaccharides, neuraminic acid and 21 lysosomal enzymes were measure...

Treponema pallidum (Nichols strain) exhibited mucopolysaccharidase activity. Acidic mucopolysaccharides were broken down more rapidly by viable treponemes than by heat-inactivated treponemes or membrane filtrates of treponemal suspensions. Ouchterlony immunodiffusion demonstrated the occurrence of antibodies to the hyaluronidase-like enzyme within syphilitic sera. After intratesticular inoculat...