Wearable tremor suppression devices (WTSD) have been considered as a viable solution to manage parkinsonian tremor. WTSDs showed their ability improve the quality of life individuals suffering from tremor, by helping them perform activities daily living (ADL). Since has shown be nonstationary, nonlinear, and stochastic in nature, performance models used is affected inability adapt nonlinear beh...

The earliest recorded description of multiple sclerosis (MS) dates back to the 14th century, but it was the French neurologist, Jean-Martin Charcot (1825–1893), who made the first definite links between the symptoms of MS and the pathological changes seen in post-mortem samples. He described the condition as “sclerose en plaques” and recognised MS as a distinct disease entity. Charcot’s contrib...

Multiple sclerosis (MS) commonly affects the cerebellum causing acute and chronic symptoms. Cerebellar signs contribute significantly to clinical disability, and symptoms such as tremor, ataxia, and dysarthria are particularly difficult to treat. Increasing knowledge concerning the pathophysiology of cerebellar disease in MS from human postmortem studies, experimental models, and clinical trial...

CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. KEY POINTS  Presynaptic inhibition of afferent feedback is known to modulate during voluntary movements  Spinal interneuron circuits have previously been demonstrated to modulate activity with the phase of ~10 Hz physiological tremor, i...

demyelinating diseases of the central nervous system (cns) are a group of autoimmune disorders affecting the myelin sheets of cns neurons resulting in different neurological deficits and disability. multiple sclerosis (ms), devic’s disease, progressive multifocal leukoencephalopathy, acute disseminated encephalomyelitis (adem), and neuromyelitis optica (nmo) are among the most common types of d...

Cerebellar ataxias represent a very heterogeneous group of disabling disorders for which we lack effective symptomatic therapies in most cases. There is currently an intense interest in the use of non-invasive transcranial DC stimulation (tDCS) to modulate the activity of the cerebellum in ataxic disorders. We performed a detailed laboratory assessment of the effects of transcranial cerebello-c...

Although there has been a significant development, in recent years, regarding disease modifying treatments (DMT) in multiple sclerosis (MS), there is a continuous need to manage the wide range of symptoms associated with MS. Although surveys vary in their results, mobility is a major concern in MS patients. However, limited evidence exists for symptomatic drug treatment and so it is important t...

introduction: excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. we hypothesized that antiglutamatergic agents would suppress harmaline tremor. from this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. material and methods: four groups of wistar rats weighing 80–100 g were injected with harmaline...

For nearly a century, functional neurosurgery has been applied in the treatment of tremor. While deep brain stimulation has been in the focus of academic interest in recent years, the establishment of incisionless technology, such as MRI-guided high-intensity focused ultrasound, has again stirred interest in lesional approaches.In this article, we will discuss the historical development of surg...

Multiple sclerosis (MS) is a well-known disease characterized by the distribution of plaques in the periventricular and subcortical white matter. Although plaques can also be found in the striatum, pallidum and thalamus, extrapyramidal symptoms are very rare in MS. However, the association of MS and parkinsonism is still a controversial topic as it has not been established whether these two con...