OBJECTIVES This study aims to examine the effect of topical mometasone furoate nasal spray on nasal Staphylococcus aureus (S. aureus) colonization in the treatment of allergic rhinitis. PATIENTS AND METHODS Between January 2012 and February 2013, 53 patients having perennial allergic rhinitis symptoms (37 females, 16 males) and 53 healthy controls (36 females, 17 males) were included in the s...

Allergic rhinitis is a common nasal disorder with a high impact on quality of life, high social costs in therapies, and a natural development towards asthma. Pharmacological therapy is based on several genres of medications, of which intranasal corticosteroids are currently the most widespread. Thermal water treatment has traditionally been used as adjunctive treatment for chronic rhinitis and ...

Department of Otorhinolaryngology, Faculty of Medicine, University of Defense Military Medical Academy, Belgrade, Serbia General Hospital Medigroup, Belgrade, Serbia Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia ENT Hospital, Dr. Zutic, Belgrade, Serbia Institute for Pharmacy, Faculty of Medicine, University of Defense Milita...

BACKGROUND Poor adherence with prescribed asthma medication is a major barrier to positive treatment outcomes. This study was designed to determine the effect of a once-daily administration of mometasone furoate administered via a dry powder inhaler (MF-DPI) on treatment adherence compared with a twice-daily administration. METHODS This was a 12-week open-label study designed to mimic an actu...

Methods All studies enrolled subjects (≥12y) with persistent asthma not well controlled on inhaled corticosteroids (ICS): study 1 (n=746 subjects with moderate persistent asthma randomized to 26wk MF/F-100/10μg, MF-100μg, F-10μg, or placebo twice daily [BID]); study 2 (n=781 subjects with moderate persistent asthma randomized to 26wk MF/F-200/10μg, MF-200μg, F-10μg, or placebo BID); study 3 (n=...

Angiogenesis, the growth and proliferation of new blood vessels, is important in a variety of pathophysiological processes. However the role of angiogenesis in allergic rhinitis has not been well studied. Hence, the aim of this study was to compare the vascularisation of the nasal mucous membrane of non-allergic, non-treated allergic and allergic patients treated with mometasone furoate. A smal...

Seasonal and perennial allergic rhinitis, acute rhinosinusitis and nasal polyposis are inflammatory conditions of the nose and/or sinuses that produce bothersome symptoms and markedly affect patients’ quality of life [1–3]. These diseases frequently coexist, suggesting that each may be a manifestation of an inflammatory process within the continuous airway [3–5]. Clinical treatment guidelines f...

BACKGROUND/AIMS In this study, we aimed to evaluate the histopathological effects of thymoquinone treatment of the nasal mucosa in a rabbit model of allergic rhinitis, and we compared its effects with those of nasal mometasone furoate. METHODS A total of 24 male New Zealand rabbits were used. The animals were randomly assigned to one of four groups. Group 1 received no treatment, while group ...

OBJECTIVE To demonstrate the long-term efficacy of intranasal furosemide, an inhibitor of the sodium chloride cotransporter channel at the basolateral surface of the respiratory epithelial cell, vs no therapeutic intervention vs intranasal mometasone furoate, a corticosteroid, in preventing relapses of chronic hyperplastic sinusitis with nasal polyposis. DESIGN Randomized prospective controll...

To better evaluate the pharmacokinetic and pharmacodynamic properties of the new inhaled glucocorticoid mometasone furoate (MF), the metabolism of MF was evaluated in rat and human tissues and in rat after i.v. administration. Metabolic studies with 3H-MF in human and rat plasma and S9 fractions of human and rat lung showed relatively high stability and a degradation pattern similar to that see...