Applications and research efforts in Mobile Learning constitute a growing field in the area of Technology Enhanced Learning. However, despite a permanent increase of mobile internet accessibility and availability of mobile devices over the past years, a mobile learning environment that is easy to use, widely accepted by teachers and learners, uses widespread off-theshelf software, and that cove...

Background: Molybden, as a vital and essential micronutrient is directly involved in the metabolism of other elements including carbon, sulfur, and nitrogen. Molybdenum alone is not biologically active unless it binds to specific cofactors. Except for the bacterial nitrogenase, which contains molybdenum-Iron complex, molybdenum cofactor (Moco) is considered as the bioactive component placed in ...

We propose a multi-objective generalisation for the well known Counting Ones problem, called the Multi-objective Counting Ones (MOCO) function. It is shown that the problem has four qualitative different regions. We have constructed a convergence time model for the Simple Evolutionary Multi-objective Optimiser (SEMO) algorithm. The analysis gives insight in the convergence behaviour in each reg...

Background Cardiac Diffusion Weighted MRI (cDWI) has the potential to characterize myocardial infarction (MI) without contrast. However, the clinical utility of cDWI has been limited by severe sensitivity to cardiac motion that manifests as signal dropouts which corrupt measures of myocardial diffusivity. This can be managed by carefully timing the diffusion encoding gradients (GDiff) to a quie...

BackgroundMyocardial T1 mapping is well established as a quantitative, non-invasive tool for myocardial tissue characterization (1). Incidence of abnormal myocardium are common in patients with cardiomyopathies but may additionally stem from anatomical misalignment due to motion (2). The latter influence not truly representative myocardium, thus result falsely elevated values and impair the ima...

The complexity of eukaryotic multicellular organisms relies on evolutionary developments that include compartmentalization, alternative splicing, protein domain fusion and post-translational modification. Mammalian gephyrin uniquely exemplifies these processes by combining two enzymatic functions within the biosynthesis of the Moco (molybdenum cofactor) in a multidomain protein. It also undergo...

Substitution therapies for orphan genetic diseases, including enzyme replacement methods, are frequently hampered by the limited availability of the required therapeutic substance. We describe the isolation of a pterin intermediate from bacteria that was successfully used for the therapy of a hitherto incurable and lethal disease. Molybdenum cofactor (Moco) deficiency is a pleiotropic genetic d...

Gephyrin is essential for both the postsynaptic localization of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (Moco) in different peripheral organs. Several alternatively spliced gephyrin transcripts have been identified in rat brain that differ in their 5' coding regions. Here, we describe gephyrin splice variants that are d...