A comparative study on tumorigenicity was carried out in which two Epstein-Barr virus (EBV) genome-positive epithelial cell lines (A2L/AH and NPC-KT) were tested in nude mice xenograft system and chick embryo system. When two cell lines were inoculated subcutaneously in nude mice and on chorioallantonic membrane of the chick embryo, respectively, tumors developed in both systems. Histologically...

We evaluated the safety and potency of Kyasanur Forest disease (KFD) vaccine inactivated with different formalin concentrations in mice, since side effects due to higher have been a major reason for refusal. Furthermore, an objective reduce use mice testing, we performed quantification KFD virus by real-time PCR compared it vivo titration mice. The prepared chicken embryo fibroblast cells was 0...

Background Quantum dots (QDs) are new types of fluorescent materials for biological labeling. QDs toxicity study is an essential requirement for future clinical applications. Therefore, this study aimed to evaluate cytotoxic effects of CdSe: ZnS QDs on male reproductive system. MaterialsAndMethods In this experimental study, the different concentrations of CdSe: ZnS QDs (10, 20 and 40 mg/kg) we...

Background The purpose was to investigate the effect of the duration of gamete incubation on fertilization rate, embryo cleavage, and embryo quality before and after freezing in mice. MaterialsAndMethods Ovulated oocytes collected from superovulated mice after ip injection of PMSG and hCG were divided randomly into control and experimental groups. Oocytes from the control group were inseminated...

BACKGROUND Embryo implantation is crucial for animal reproduction. Unsuccessful embryo implantation leads to pregnancy failure, especially in human-assisted conception. Environmental factors have a profound impact on embryo implantation. Because people are being exposed to more light at night, the influence of long-term light exposure on embryo implantation should be explored. METHODS The eff...

Background: Diabetes is a metabolic disorder that in long period can damage the testis and reduce the semen quality. Therefore, it can impair the male fertility potential. Recently, different herbal therapeutic treatment for protection of diabetes and its pathologic effects have been used. The aim of current study is to evaluate the protective effect of Equisetum arvense extract (EE) on in vitr...

background: quantum dots (qds) are new types of fluorescent materials for biological labeling. qds toxicity study is an essential requirement for future clinical applications. therefore, this study aimed to evaluate cytotoxic effects of cdse: zns qds on male reproductive system. materials and methods: in this experimental study, the different concentrations of cdse: zns qds (10, 20 and 40 mg/kg...

The effect of dosage and pretreatment with phénobarbital or 2-diethylaminoethyl-2,2-diphenylvalerate on the binding of labeled cyclophosphamide and/or its metabolites to macromolecular constituents of the embryo and maternal liver in pregnant mice was studied under conditions nearly identical to those of previous studies of cyclophosphamide teratogenicity. Cyclophosphamide and/or its metabolit...

The prevalence of diabetes is increasing worldwide with the trend of patients being young and creating a significant burden on health systems, including reproductive problems, but the effects of diabetes on embryo implantation are still poorly understood. Our study was to examine effects of diabetes on mouse embryo implantation, providing experimental basis for treating diabetes and its complic...

background: pregnancy is one of the changer agents for defensive cells, however it is unknown the effect of the ethanolic extract of the salvia officinalis on the uterine natural killer cells population in the pregnant mice that needs to be investigated. objective: the aim of this study was to determine the effect of the ethanolic extract of the salvia officinalis on the uterine natural killer ...