Dexamethasone, a synthetic glucocorticoid, decreases the plasminogen activator (PA) activity of HTC rat hepatoma cells in tissue culture. Paradoxically, dexamethasone enhances the cyclic nucleotide stimulation of PA activity in these cells 2-4-fold. In this report, we investigated whether this paradoxical glucocorticoids as the induction of tyrosine aminotransferase activity. We compared the co...

The sex of Japanese flounder (Paralichthys olivaceus) is easily altered by water temperature or sex steroid hormone treatment during the period of sex determination. We have previously shown that rearing the genetically female larvae at high water temperature caused the suppression of P450 aromatase (P450arom) gene expression in the gonad and phenotypic sex-reversal of the individuals to males ...

N U T R I T I O N can markedly affect carcass leanness. There is evidence, recently reviewed by Wallace et al. (1966), that dietary restriction of either energy or total diet will bring about increased carcass leanness. Several workers have also reported improvement in carcass desirability with increasing levels of dietary protein or lysine (Ashton et al., 1955; Cahilly et al., 1963; Wagner et ...

14.3 Pharmacology of testosterone preparations 14.3.1 Oral administration 14.3.1.1 Unmodified testosterone 14.3.1.2 17 -methyltestosterone 14.3.1.3 Fluoxymesterone 14.3.1.4 Mesterolone 14.3.1.5 Testosterone undecanoate 14.3.2 Sublingual application 14.3.3 Buccal application 14.3.4 Nasal application 14.3.5 Rectal application 14.3.6 Intramuscular application 14.3.6.1 Testosterone propionate 14.3....

The transcription factor sox9 has been implicated in cartilage formation and testis determination in mammals. Here, two duplicates of sox9 were found in Japanese flounder (Paralichthys olivaceus) named Posox9a and Posox9b, respectively. Phylogenetic and gene structure analyses revealed that Posox9a and Posox9b were homologous to that of teleosts and tetrapods. Quantitative real-time polymerase ...

The aim of this study was to develop an enzyme-linked immunosorbent (ELISA) assay to quantify spiggin in the three-spined stickleback. Spiggin is a glue protein produced in the kidney of male three-spined stickleback under the control of androgens during the breeding period. Disturbances of spiggin production in male fish and abnormal induction of spiggin in female fish are considered as valuab...

Estrogen is an active neuroprotectant and is presently investigated as a potential therapy against Alzheimer's disease for women. To determine if male hormones could also be neuroprotective, we investigated the effect of testosterone, methyltestosterone, and epitestosterone at physiological concentrations on primary cultures of human neurons induced to undergo apoptosis by serum deprivation. Se...

17 α Methyl testosterone is a synthetic steroid hormone having androgenic properties. It used in aquaculture, medical treatments, sports as doping drugs, improving food efficacy but its residue meat and their products can cause risk to the human, animals environment. In this article, we have focused on developing homologous ELISA using 17α testosterone-3-Carboxymethyloxime-Bovine serum albumin ...

in a double blind, parallel-group, clinical trial we compared the effects of conjugated estrogen with estrogen plus methyltestosterone in surgically menopausal women. in this study, 251 women were randomly assigned to one of the two regimens: 1-conjugated estrogen 0.625 mg/day +placebo. 2-conjungated estrogen 0.625 mg/day+methyltestosterone 1.25 mg/day (e+a group). study parameters were psychol...