High throughput experiments, characteristic of studies in systems biology, produce large output data sets often at different time points or under a variety of related conditions or for different patients. In several recent papers the data is modeled by using a distribution of maximal information-theoretic entropy. We pose the question: ‘whose entropy’ meaning how do we select the variables whos...

In many applications, the use of Bayesian probability theory is problematical. Information needed to feasibility calculate is unavailable. There are different method-ologies for dealing with this problem, e.g., maximal entropy and Dempster-Shafer Theory. If one can make independence assumptions, many of the problems disappear, and in fact, this is often the method of choice even when it is obvi...