Antibodies targeting the PD-1/PD-L1 immune checkpoint lead to tumor regression and improved survival in several cancers. PD-L1 expression in tumors may be predictive of response to checkpoint blockade therapy. Because tissue samples might not always be available to guide therapy, we developed and evaluated a humanized antibody for non-invasive imaging of PD-L1 expression in tumors. Radiolabeled...

This study investigated the effect of treatment in the second language (L2) for a previously proficient French-English bilingual with aphasia, at 5 years post-stroke. Assessment on the Bilingual Aphasia Test (BAT) enabled objective measurement of language skills in each language, and comparison across languages, before and after treatment in L2 (English). Previous therapy had been provided excl...

| This paper considers vector quantization of signals using the L1 distortion measure. The key contribution is a result that allows one to characterize the cen-troid of a set of vectors for the L1 distortion measure. A method similar to the LBG algorithm for designing code-books has been developed and tested. The paper also discusses the design of vector quantizers employing the L1 distortion m...

the present study investigated the effect of marginal glosses (both l1 and l2) on incidental vocabulary learning of efl learners. the subject pool consisted of 154 third-semester iranian students enrolled at azad university, central branch. after administering a proficiency test, 90 homogeneous students were assigned to two experimental groups (x1 & x2) and one control group. afterwards, a 50 -...

The cell adhesion molecule L1 (L1-CAM) plays important functional roles in the developing and adult nervous systems. Here we show that peripheral nerve injury induced dynamic post-transcriptional alteration of L1-CAM in the rat dorsal root ganglia (DRGs) and spinal cord. Sciatic nerve transection (SCNT) changed the expression of L1-CAM protein but not L1-CAM mRNA. In DRGs, SCNT induced accumula...

| This paper considers the vector quantization of signals using the L1 distortion measure. The key contribution is a result that allows one to characterize the centroid of a set of vectors for the L1 distortion measure. A method similar to the LBG algorithm for designing codebooks has been developed and tested. The paper also discusses the design of vector quantizers employing the L1 distortion...

Adult second language learners often show considerable individual variability in the ease with which lexical tones are learned. It is known that factors pertaining to a learner’s first (L1; such as L1 tonal status or tone type) well extralinguistic (such musical experience and working memory) modulate learning facility. However, how L1-specific affect performance together dynamic ways less unde...