Three genetic loci in the mouse affect the synthesis and assembly of the erythrocyte membrane skeleton. The spherocytosis and jaundiced loci affect the membrane skeletal protein known as spectrin. The normoblastosis locus affects the spectrin binding protein called ankyrin. We have obtained genetic data that define the linkage relationships among three spectrin genes and the spherocytosis and j...

Patients with obstructive jaundice frequently suffer postoperative complications. We have investigated the relationship of obstructive jaundice to the neutrophil oxidase response and the "priming" of the response by the cytokines TNF alpha, interleukin-1 (IL-1), IL-6, and IL-8. On stimulation with f-met-leu-phe (fmlp), the respiratory burst in neutrophils from jaundiced patients was greatly inc...

The authors present a case of patient with severe hyperbilirubinemia due to acute hepatitis B infection which resolved without intervention subsequent normalization synthetic and excretory liver function. Despite this, the remained jaundiced unconjugated in context recent diagnosis flare hereditary spherocytosis. Due complex clinical presentation, underwent biopsy additional genetic Gilbert’s S...