INTRODUCTION Ketamine is an agent broadly used for pediatric procedural sedation and analgesia in emergency departments. It has been found to be safe and with a low risk of complications. Choosing between intravenous (IV) and intramuscular (IM) injections is a matter of concern, so we did a comparison between the two methods in terms of their efficacy and rate of complications. METHODS This s...

BACKGROUND A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant depression (TRD). Here we tested the tolerability, safety, and efficacy of repeated-dose open-label IV ketamine (six infusions over 12 days) in 10 medication-free symptomatic patients with TRD who had previously shown a meaningful antidep...

OBJECTIVES The authors sought to compare the safety and efficacy of subdissociative-dose ketamine versus fentanyl as adjunct analgesics for emergency department (ED) procedural sedation and analgesia (PSA) with propofol. METHODS This double-blind, randomized trial enrolled American Society of Anesthesiology (ASA) Class I or II ED patients, aged 14-65 years, requiring PSA for orthopedic reduct...

BackgroundAlthough midazolam and ketamine are widely administrated as oral premedications for children, only a few studies have investigated the cardiovascular, respiratory and sedative effects of these drugs in children with congenital heart disease (CHD). MethodsWe compared three methods of administering midazolam and ketamine and a combination of these two drugs as an oral premedication in 1...

Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain required both hydromorphone and ketamine for a period of over four months. There was no evidence of ...

background pain control in children is still a therapeutic dilemma. preschool patients are affected from undesirable effects of postoperative pain more than adults. tonsillectomy is associated with a high incidence of postoperative pain, not only complicating the recovery, but also delaying patients discharge. objectives despite employing different surgical and anesthetic strategies in post-ton...

BACKGROUND Aquafol, a microemulsion propofol, causes more severe and frequent pain on injection than propofol. The purpose of this study was to compare a combination of lidocaine and ketamine on aquafol-induced pain with lidocaine or ketamine alone during the induction of anesthesia. METHODS In this prospective, randomized, double-blinded study, 130 healthy patients who were undergoing electi...

Study Objective: This study was designed to evaluate the effect of preemptive use of intravenous acetaminophen, ketamine or their combination on intraoperative and postoperative analgesic requirements in patients undergoing elective open abdominal and urological surgeries under general anesthesia. Setting: Beni Suef University Hospital, Egypt. Patients and Interventions: 80 ASA I-II patients un...

BACKGROUND There is a lack of consensus regarding second-line therapy in children with acute asthma who fail to the standard therapy. Ketamine had bronchodilator property and may be useful in the treatment of acute asthma. OBJECTIVE The objective of this study was to evaluate the efficacy and safety of ketamine as compared to aminophylline in children with acute asthma who respond poorly to t...

UNLABELLED Recent advances in acute pain mechanisms and management have implicated the N-methyl D-aspartate receptor-ion channel complex in the development of postoperative hyperalgesia and acute opioid tolerance. N-methyl D-aspartate receptor antagonists such as ketamine have been used increasingly in clinical studies in an effort to minimize acute postoperative pain and reduce opioid requirem...