نتایج جستجو برای: itpa
تعداد نتایج: 206 فیلتر نتایج به سال:
The purine analogues tenofovir and abacavir are precursors of potential substrates for the enzyme Inosine 5'-triphosphate pyrophosphohydrolase (ITPase). Here, we investigated the association of ITPase activity and ITPA genotype with the occurrence of adverse events (AEs) during combination antiretroviral therapy (cART) for human immunodeficiency virus (HIV) infection. In 393 adult HIV-seroposit...
42 Background 43 Polymorphisms of the ITPA gene have been associated with anemia during 44 combination therapy in HCV mono-infected patients. Our aim was to confirm this 45 association in HIV/HCV co-infected patients 46 Methods 47 In this prospective, observational study, 73 HIV/HCV co-infected patients treated with 48 Peg-IFN plus RBV were enrolled. Two SNPs within or adjacent to ITPA gene (rs...
ix CHAPTER I. EPILEPSY 1 Historical Perspective .... 2 Current Concepts and Diagnosis 4 Classification of the Epilepsies 7 Grand Mai 8 Petit Mai 9 Temporal Lobe or Psychomotor Seizures 10 Jacksonian 10 Prevalence 13 II. PSYCHOLOGICAL STUDIES OF CHILDREN WITH EPILEPSY. 16 The Intelligence of Epileptics 18 Institutionalized and Public School Epileptics 20 The Effects of Brain Damage 22 Deteriorat...
Background and aim: Conventional hepatitis C treatment using pegylated interferon (PEG-IFN) and ribavirin is associated with significant side effects. IL28B polymorphism can predict response to treatment, with CC genotype having a better response. ITPA gene deficiency protects against clinically significant anaemia induced by treatment. The purpose of this study was to determine IL28B polymorph...
In general, twins have delayed language development early in childhood compared with singletons. The purpose of this study was to clarify the overall linguistic features of twins. A Japanese version of the Illinois Test of Psycholinguistic Abilities (ITPA) was administered in 24 twin pairs (aged 3 to 4 years) at their own homes. The overall language abilities of the twins were in the normal ran...
The structure of human inosine triphosphate pyrophosphohydrolase (ITPA) has been determined using diffraction data to 1.6 A resolution. ITPA contributes to the accurate replication of DNA by cleansing cellular dNTP pools of mutagenic nucleotide purine analogs such as dITP or dXTP. A similar high-resolution unpublished structure has been deposited in the Protein Data Bank from a monoclinic and p...
BACKGROUND Human genetic factors influence the outcome of pegylated interferon and ribavirin hepatitis C therapy. We explored the role of IL28B, APOH and ITPA SNPs on the outcomes of triple therapy including telaprevir or boceprevir in patients with compensated cirrhosis chronically infected with HCV-1. PATIENTS AND METHODS A total of 256 HCV-1 Caucasian treatment-experienced patients with co...
هیپرتروفی قلبی (hcm) یکی از شایع ترین بیماری های قلبی-عروقی است و علامت بارز آن افزایش ضخامت دیواره بطن چپ در غیاب بار افزایش یافته خارجی است. hcm وdcm عمدتا" به واسطه جهش در ژن های کد کننده پروتئین های سارکومری رخ می دهند. اما اخیرا" مشخص شده است که موش هایی که ژن itpa در آن ها ناک اوت شده است علائمی شبیه hcm در انسان نشان می دهند. ژن itpa کد کننده ی آنزیم سیتوزولیitpase می باشد که نقش مهمی را...
Feedback is one of the most influential factor when it comes to learning success of students. Especially large-scale classes at universities often lack feedback caused by the scarcity of resources. Even though a lack of feedback is problematic across all domains, it is especially crucial when aiming to educate future managers, who are supposed to lead team members by providing effective feedbac...
Inosine triphosphate pyrophosphatase (ITPA), a key enzyme involved in maintaining the purity of cellular nucleoside triphosphate pools, specifically recognizes inosine triphosphate and xanthosine triphosphate (including the deoxyribose forms) and detoxifies them by catalyzing the hydrolysis of a phosphoanhydride bond, releasing pyrophosphate. This prevents their inappropriate use as substrates ...
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