The independent association between the indices of iron stores or administered intravenous iron, both of which vary over time, and survival in patients who are on maintenance hemodialysis (MHD) is not clear. It was hypothesized that the observed associations between moderately high levels of three iron markers (serum ferritin, iron, and iron saturation ratio) or administered intravenous iron an...

BACKGROUND Recommendations given for intravenous iron treatment are typically not supported by a high level of evidence. This meta-analysis addressed this by summarising the available date from clinical trials of ferric carboxymaltose using clinical trial reports and published reports. METHODS Clinical trial reports were supplemented by electronic literature searches comparing ferric carboxym...

BACKGROUND The objective of this study was to compare the efficacy, safety and tolerability of intravenous iron sucrose with that of oral ferrous fumarate in iron deficiency anemia during 14 to 34 weeks of pregnancy. METHODS A randomized controlled trial was performed involving 112 patients attending the antenatal clinic at Shri B.M.Patil Medical college Hospital, Bijapur from October 2011 to...

BACKGROUND Functional iron deficiency (FID) may cause erythropoietin resistance in patients under hemodialysis (HD). Since the role of chronic inflammation or oxidative stress in its pathogenesis is unclear, controversy remains to whether intravenous iron or intravenous ascorbic acid (an antioxidant) can improve this anemia due to decreased iron availability. OBJECTIVES The current study comp...

Inflammatory bowel disease (IBD) is associated with chronic intestinal inflammation, complications, and variable extraint-estinal manifestations. 1-3 Although anemia is one of the most common extraintestinal manifestations and can affect quality of life in patients with IBD, it's clinical importance has been underestimated. However, in a recently issued Western guideline, which placed focused o...

BACKGROUND In patients treated by maintenance hemodialysis the relationship to survival of hemoglobin level and administered epoetin-alfa and intravenous iron is controversial. The study aim was to determine effects on patient survival of administered epoetin-alfa and intravenous iron, and of hemoglobin and variables related to iron status. METHODS The patients were 1774 treated by maintenanc...

BACKGROUND Intravenous iron therapy is a treatment option for iron deficient patients who are intolerant to oral iron or where oral iron is ineffective, but with possible adverse effects. Currently, prospective studies comparing different intravenous iron formulations are needed to determine safety and efficacy of these agents. METHODS We conducted a prospective, double-blind, randomized cont...

A moderate degree of anaemia is commonly present in patients with rheumatoid arthritis. The anaemia is usually normocytic and hypochromic and the degree of anaemia roughly parallels the activity of the disease (Nilsson, 1948; Jeffrey, 1953a). Among the varied features described in anaemia associated with arthritis are alterations in plasma volume causing anaemia through hydraemia (Robinson, 194...

I N THE THERAPY of iron-deficiency anemia, iron given orally is safe, effective, inexpensive, and is usually the treatment of choice, but occasionally when a rapid replenishment of iron stores is desired, administration by the parenteral route is indicated. Heath, Strauss and Castle,1 in 1938, showed that when 16-32 mg. of iron as ferric ammonium citrate is injected subcutaneously or intramuscu...