Considerable evidence both in vitro and in vivo suggests that alcohols exert their intoxicating properties through an interaction with membranes. A wide range of alcohols and diols with divergent structures induce a virtually identical spectrum of intoxication signs. Because of their pharmacological similarities to ethanol, a number of aliphatic diols were tested to determine whether this class...

Introduction: Paraquat (1,1’-dimethyl-4, 4’-dipyridylium) intoxication is a major medical problem in developing countries. The ingestion of paraquat is fatal in humans and its mortality rate is as high as 50%. Paraquat intoxication has a systemic effect on the lung, kidney, gastrointestinal tract, central nervous system, and even on the heart. Case report: A female patient visited our emergency...

Amitraz is commonly used in agricultural industries throughout the world as a farm-animal insecticide. Despite its widespread use, amitraz intoxication is extremely rare and mainly occurs through accidental ingestion by young children. Severe, life-threatening amitraz intoxication in adults is very rarely recognized and reported. Described herein is a previously healthy 54-year-old patient who ...

We report a case of a 66-year-old patient with paraquat intoxication resulting in the requirement for hemoperfusion, hemodialysis, and plasma exchange. His initial serum paraquat level was 0.24 µg/mL (0.0-0.1 µg/mL). Activated charcoal (50 g) was administered orally, and high-dose N-acetylcysteine (150 mg/kg) was administered intravenously. In addition, immediate 4 h hemoperfusion was also perf...

Trihexyphenidyl or Artane® /Parkinane® is an anti-cholinergic drug belonging to the antimuscarinic class. It used in treatment of Parkinson’s disease and widely psychiatry for management extrapyramidal side effects neuroleptics. Its overdose leads a central peripheral anticholinergic syndrome. We report here case seven-year-old Senegalese boy who developed signs intoxication due accidental inge...

Mental retardation is progressive in Down syndrome: individuals are born with normal intelligence which starts to decline linearly within the first year. This phenomenon can be observed with phenylalanine in patients with phenylketonuria, therefore it is compatible with metabolic intoxication. The toxic compound could be hydrogen sulfide. The amount of the compound is probably increased in Down...

BMJ 1993;307:1579-82 Abstract Objective-To determine whether the incidence of chronic sinusitis, bronchitis, or bronchiectasis in men with obstructive azoospermia (Young's syndrome) has fallen in men born after 1955 when calomel (mercurous chloride) was removed from teething powders and worm medication in the United Kingdom. Design-A prospective study of aetiological factors in subfertile men w...

Endogenous toxins are protein molecules whose content in the blood is determined by destruction of cells. Not being normal components plasma, they subject to elimination from bloodstream. Due accumulation endogenous toxic substances, intoxication a frequent complication many acute and chronic diseases respiratory system. The present study revealed significant increase markers tubular lesion chi...