The RosettaAntibody server (http://antibody.graylab.jhu.edu) predicts the structure of an antibody variable region given the amino-acid sequences of the respective light and heavy chains. In an initial stage, the server identifies and displays the most sequence homologous template structures for the light and heavy framework regions and each of the complementarity determining region (CDR) loops...

Group a allotypes not detected by qualitative typing or anticipated from breeding data (latent allotypes) were detected at low levels in 50% of normal rabbit sera tested. The latent allotypes, which were serologically identical to allotypes of pooled IgG, were detected in sera from rabbits with all possible combinations of group a allotypes and their occurrence in individual rabbits was transit...

conclusions sequence and structural diversity of the 3'utr variable region and poly u/uc region found in the local isolates indicate specificity in the regulating elements of 3'utr that might be associated with differential replication efficacy of the hcv pakistani isolates. the study necessitates functional characterization of these regulating elements to elucidate variable viral eff...