According to the National Committee for Clinical Laboratory Standards (NCCLS, 2004), a method to evaluate the inducible clindamycin resistance in accordance with an approach of the disks of erythromycin and clindamycin--the D test--has been reported. We analyzed the performance of this method in 200 coagulase negative staphylococci (CoNS) strains obtained from blood cultures of hospitalized pat...

background staphylococcus aureus is a common pathogen in hospitals and communities. antibiotic resistance is a major public health problem. objectives the aim of this study was the determination of antimicrobial susceptibility patterns and to perform molecular detection of macrolide and lincosamide-resistance genes in clinical s. aureus isolates from kerman, iran. conclusions a high prevalence ...

INTRODUCTION Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. MATERIALS AND METHODS The detection of inducible clindamycin resistance was performed by D...

objective(s): nitric oxide (no), a product of inducible nitric oxide synthase (inos), contributes in germ cell apoptosis. this study was aimed to evaluate the effects of aloe vera gel (avg) on male wistar rat reproductive organ, serum no level, and expression of inos gene in leydig cells. materials and methods:adult male wistar rats (n=36) were used for experiments in three groups. the experime...

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The incidences of inducible clindamycin resistance at two hospitals (an inner-city hospital and a suburban community hospital) were 7 and 12% for methicillin-resistant Staphylococcus aureus, 20 and 19% for methicillin-susceptible S. aureus, and 14 and 35% for coagulase-negative staphylococci, respectively. Given the variability of inducible resistance to clindamycin found in our two hospitals, ...

Clindamycin is one of the important alternative antibiotics in the therapy of Staphylococcus aureus infections. Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolides, lincosamides and Streptogramin B (MLSB) antibiotics. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance due...

Clindamycin has been used to treat serious infections caused by susceptible Staphylococcus aureus strains in children for more than 30 years. It remains effective for many infections caused by community-acquired methicillin-resistant S. aureus (CAMRSA). Clindamycin also is useful for selected infections caused by pneumococci, group A streptococci, and a number of other microbes. Absorption afte...

BACKGROUND AND OBJECTIVES Resistance to macrolide can be mediated by erm and msrA genes in Staphylococcus aureus. There are the evidences that show erm genes may be causative agent of inducible or constitutive resistance. The aim of this study was to investigate the incidence of inducible clindamycin resistance and determine the most frequency of erm and msrA genes among S. aureus isolates. M...

9 Clindamycin is increasingly used to treat canine pyoderma. Eight of 608 Staphylococcus 10 pseudintermedius isolates were positive for inducible clindamycin resistance by D-test and PCR 11 detection of ermB. Staphylococcus pseudintermedius isolates that are erythromycin-resistant but 12 clindamycin-susceptible by in vitro antimicrobial susceptibility testing should be tested for 13 inducible c...