It is not unusual for clinicians, particularly for those working in gastroenterology, to find intestinal villus atrophy (IVA) in duodenum biopsies from patients treated with chronic diarrhoea. In most cases, this finding rules out the existence of coeliac disease (CD)1. CD is an autoimmune disease that mostly develops in genetically predisposed subjects carrying HLA-DQ2/DQ82. To obtain a defini...

BACKGROUND The most common neurologic manifestation of gluten sensitivity is ataxia, which accounts for up to 40% of idiopathic sporadic ataxia. Timing of diagnosis of gluten ataxia is vital as it is one of the very few treatable causes of sporadic ataxia and causes irreversible loss of Purkinje cells. Antigliadin antibody (AGA) of the IgG type is the best marker for neurological manifestations...

background: the most common neurologic manifestation of gluten sensitivity is ataxia, which accounts for up to 40% of idiopathic sporadic ataxia. timing of diagnosis of gluten ataxia is vital as it is one of the very few treatable causes of sporadic ataxia and causes irreversible loss of purkinje cells. antigliadin antibody (aga) of the igg type is the best marker for neurological manifestation...

Dokuz Eylul University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Izmir, TURKEY Celiac disease (CD) is a common immune-mediated enteropathy triggered by gluten in genetically susceptible individuals with an overall prevalence almost 1% in different countries [1]. The diagnosis of the disease is classically based on a combinat...

Fifteen patients with intestinal villous atrophy, but simultaneously negative results of antiendomysial antibodies (EMA) were studied. Two patients were finally diagnosed as having coeliac disease. The predictive value of negative results of EMA assessment in children suspected of coeliac disease is high, approaching 86.7%.

Formation of DNA adducts chemical carcinogens is a trigger for carcinogenesis. Adducts benzo[a]pyrene metabolites and estradiol with have been found in normal tumor cells healthy women patients breast colorectal cancer. These low-weight compounds macromolecular complexes induce the synthesis specific antibodies. Previously, presence antibodies against (IgA-Bp), (IgA-Es) progesterone (IgA-Pg) wa...