AIMS Insulin resistance, dyslipidemia and hypertension are independent mediators of endothelial dysfunction. It is incompletely defined whether dyslipidemia and hypertension in addition to diabetes mellitus type II (DMII), as seen in the metabolic syndrome (MS), worsen diabetes-induced endothelial dysfunction. Furthermore, it is unclear whether treatment influences endothelial dysfunction simil...

Abstract Context Hyperglucagonaemia may develop in type 2 diabetes due to obesity-prone hepatic steatosis (glucagon resistance). Markers of glucagon resistance (including the glucagon-alanine index) improve following diet-induced weight loss, but partial contribution lowering versus body is unknown. Objective To investigate dependency loss a reduction on markers diabetes. Design and setting A p...

conclusions aed improved liver enzymes in obese women. however, mild, transient increases in alt and ast values can be observed immediately after an nfd in women. results of 108 participants, 50 women in aed group and 50 women in nfd group completed the protocol of the study (response rate: 92.6 %). the aed led to a median weight loss of 3.79 kg (interquartile range: 4.4 kg). significant decrea...

BACKGROUND The replacement of sucrose with HFCS in food products has been suggested as playing a role in the development of obesity as a public health issue. The objective of this study was to examine the effects of four equally hypocaloric diets containing different levels of sucrose or high fructose corn syrup (HFCS). METHODS This was a randomized, prospective, double blind trial, with over...

Zinc is required for many biological functions including DNA synthesis, cell division, gene expression and the activity of various enzymes in humans and animals. Zinc concentrations in the plasma and erythrocytes are lower and urinary zinc excretion and serum insulin levels are higher in subjects with obesity. The effects of a weight-loss program based on a hypocaloric balanced diet were invest...

OBJECTIVE Weight loss reduces abdominal and intrahepatic fat, thereby improving metabolic and cardiovascular risk. Yet, many patients regain weight after successful diet-induced weight loss. Long-term changes in abdominal and liver fat, along with liver test results and insulin resistance, are not known. RESEARCH DESIGN AND METHODS We analyzed 50 overweight to obese subjects (46 ± 9 years of ...

OBJECTIVE To investigate the role of hypocaloric highprotein diet, a prospective clinical study was conducted in NAFLD patients. RESEARCH METHODS AND PROCEDURES Pre-versus post-interventional data were analyzed in 48 stable NAFLD patients (submitted to a hypocaloric high-protein diet during 75 days. Variables included anthropometrics (body mass index/ BMI and waist circumference/WC), whole-bo...

OBJECTIVE Although weight loss interventions have been shown to reduce steatosis in nonalcoholic fatty liver disease (NAFLD), the impact of dietary macronutrient composition is unknown. We assessed the effect on serum alanine aminotransferase (ALT) concentrations of two hypocaloric diets varying in amounts of carbohydrate and fat in obese insulin-resistant individuals, a population at high risk...

BACKGROUND Cross-sectional studies have identified a high intake of simple sugars as an important dietary factor predicting nonalcoholic fatty liver disease (NAFLD). OBJECTIVE We examined whether overfeeding overweight subjects with simple sugars increases liver fat and de novo lipogenesis (DNL) and whether this is reversible by weight loss. DESIGN Sixteen subjects [BMI (kg/m²): 30.6 ± 1.2]...