BACKGROUND One of the acquired biological hallmarks of tumor multistep development is the resistance of cancer cells to apoptosis; therefore, induction of apoptosis is an important therapeutic approach. Hypericum species are spread throughout the world and have been investigated for their biological properties. OBJECTIVES Our previous studies had demonstrated cytotoxicity of Hypericum scabrum...

The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea, Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing antiviral, anti-inflammatory and anti-pain activities. This mini-review reports on ongoing studies on Hypericum. The Center uses the genetically diverse, well-documented Hypericum populations collected and maintained at th...

Hypericum perforatum, commonly known as St. John’s Wort, has been found to exhibit many medicinal, especially anti-depressant, properties. Hypericin is thought to be the main chemical constituent responsible for H. perforatum’s medicinal properties. We report here the ability of H. perforatum and hypericin to inhibit the growth of mouse mammary cancer CRL2539 cells. H. perforatum, at concentrat...

AIM To evaluate the effects of montelukast and Hypericum perforatum against ischemia/reperfusion (I/R)-induced intestinal damage. MATERIALS AND METHODS Twenty-eight hamsters were divided into 4 groups following midline abdominal laparotomy: control group (n = 7), I/R group (n = 7), montelukast and I/R (MIR) group (n = 7), and Hypericum perforatum and I/R (HPIR) group (n = 7). After 60 min of ...

BACKGROUND A number of bio-active secondary metabolites have been identified and reported for several Hypericum species. Many studies have reported the potential use of the plant extracts against several pathogens. However, Hypericum triquetrifolium is one of the least studied species for its antimicrobial activity. The aim of the present study was to evaluate the cytotoxic effect of the essent...

BACKGROUND St John's wort (Hypericum perforatum) has been known for centuries for its therapeutic properties and its efficacy as an antidepressant has been confirmed by a growing body of evidence. During the last two decades it has also come to prominence with a wider public, due to advertising efforts across Europe and United States of America. However, its availability without prescription, a...

The genus Hypericum (Hypericaceae) has attracted remarkable scientific interest as its members accumulate significant amounts of various bioactive compounds. In the current study, we investigated accumulation of several bioactive compounds in various parts of Hypericum hircinum L. subsp. majus (Ainton) N. Robson, H. pallens Banks et Sol., H. russeggeri (Fenzl) R. Keller and H. lanuginosum Lam. ...

Hypericum perforatum, is a plant which blooms between july and september at farms, borders of roads and woods, top of hills and grasslands, whose anti-inflammatory effects are shown in various studies. It is shown that cigarette smoke causes increase in inflammation mediators on lung. Due to this reason, we planned a study to examine the protective effects of Hypericum perforatum aganist smoke ...

Several modes of reproduction were described in the genus Hypericum. Besides obligate sexuality, irregularities in meiosis, polyembryony and pseudogamous apomixis were noticed in various taxa of the genus. This review summarizes previous knowledge and also analyses evolutionary consequences of different breeding systems and possible employment of particular reproductive modes for breeding in th...