INTRODUCTION Neuropathic pain is defined as pain arising as a direct consequence of a lesion or disease affecting the somatosensory system and is common after surgery. Neuropathic pain can persist without an obvious injury. In this study we aim to validate a murine chronic constriction injury model as a model for neuropathic pain research and determine if silk or catgut ligatures induced most s...

Besides its approval as an adjunctive anticonvulsant, gabapentin was reported to be effective in neuropathic and inflammatory pain. Antihyperalgesic effect of gabapentin may be related to possible antiinflammatory activity. We aimed to examine the antiinflammatory effect of chronic gabapentin administration on inflammatory response in rats. Experiments were performed with the permission of the ...

Anti-inflammatory activity of the ethanolic extract of the leaves of Morus indica Linn. was studied in wistar rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (100 mg/kg, p.o.) inhibited carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction...

Sphaeranthus indicus had been widely used for its reported biological activity in indigenous system of medicine. The present investigation was carried out to find the anti-inflammatory effect of ethanolic extract of Sphaeranthus indicus in albino rats. The anti-inflammatory activity was evaluated using acute inflammatory model like carrageenan induced paw edema and chronic inflammatory model li...

Prednisolone is an analgesic and anti-inflammatory drug. It possesses poor aqueous solubility and has irritant effects on stomach mucosa. In order to modulate its gastric side effect and increase aqueous solubility, physical mixture and solid dispersion of prednisolone were prepared with skimmed milk. In this study, anti-inflammatory and analgesic effects of these formulations were investigated...

Acute pharyngitis is characterized by an inflammation of the mucous membranes in the pharynx. Yanshu spraying agent was prepared according to the traditional Chinese formulation for the treatment of acute pharyngitis. The present study aimed to investigate the anti-inflammatory effect of Yanshu in xylene-induced ear edema in mice and carrageenan-induced paw edema in rats by measuring the degree...

Prednisolone is an analgesic and anti-inflammatory drug. It possesses poor aqueous solubility and has irritant effects on stomach mucosa. In order to modulate its gastric side effect and increase aqueous solubility, physical mixture and solid dispersion of prednisolone were prepared with skimmed milk. In this study, anti-inflammatory and analgesic effects of these formulations were investigated...

Objective: To evaluate the antiinflammatory effects of Morphine and Gabapentin alone and as adjuvant with diclofenac by using formalin induced paw edema model. Methods: After acclimatization of one week, adult Sprague-Dawley rats were divided into two groups: control and treatment (n=6). Treatment group received diclofenac (10 mg/kg), gabapentin (150 mg/kg), morphine (15 mg/kg), gabapentin (150...

Inflammation is a response to tissue damage due various adverse stimuli, both chemical and mechanical, infections foreign bodies such as bacteria viruses. This study aims determine the effect of anti-inflammatory ethanol extract karamunting stems. Karamunting stems were extracted by maceration method using 96% solvent. Each anti-inflamatory test was divided into five groups, namely negative con...