نتایج جستجو برای: hepatotoxic
تعداد نتایج: 1645 فیلتر نتایج به سال:
High affinity antisense oligonucleotides (ASOs) containing bicylic modifications (BNA) such as locked nucleic acid (LNA) designed to induce target RNA cleavage have been shown to have enhanced potency along with a higher propensity to cause hepatotoxicity. In order to understand the mechanism of this hepatotoxicity, transcriptional profiles were collected from the livers of mice treated with a ...
Background: Doxorubicin is an effective chemotherapeutic drug, but its toxic potential limits use. Aim: To study the effects of doxorubicin on relative tissue weight index and hepatic central vein diameter in albino rats. Study Design: Experimental Place Duration study: was conducted 20 adult rats both male female gender animal house Anatomy department, (PGMI) Lahore, Pakistan April 2019. Mater...
The toxicity of vinylidene chloride (VDC) was studied in mice and rats exposed to various concentrations of the vapors for 23 hr/day. In addition, the ability of various treatments to alter parameters of toxicity was evaluated. Mice were more sensitive than rats both to the acute lethal and hepatotoxic effects of VDC. Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inha...
Hepatotoxic plants are important cause of economical losses in farm animals in Brazil. This report concerns an outbreak of acute hepatic toxicosis, in which seven goats died after consumption of green leaves from a felled Trema micrantha tree. Two of these animals were necropsied and several tissues were processed for histological examination. Main histological finding was observed in the liver...
Recently, the European Medicines Agency (EMEA) and the Committee on Herbal Medicinal Products (HMPC) have released a public statement to draw the attention of European health authorities to 42 cases (34 directly reported from European national competent authorities and 8 published) of suspected hepatotoxic reactions to Cimicifugae racemosae rhizoma (black cohosh, root) in patients, probably all...
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