نتایج جستجو برای: hbsag epitopes mutations

تعداد نتایج: 201746  

2016
Yih-Lin Chung Mei-Ling Wu

Proteasome-mediated degradation of promyelocytic leukemia tumor suppressor (PML) is upregulated in many viral infections and cancers. We previously showed that PML knockdown promotes early-onset hepatocellular carcinoma (HCC) in hepatitis B virus surface antigen (HBsAg)-transgenic mice. Here we report the effects of PML restoration on late-onset HBsAg-induced HCC. We compared protein expression...

2017
Romina Salpini Matteo Surdo Nadia Warner Maria Francesca Cortese Danny Colledge Sally Soppe Maria Concetta Bellocchi Daniele Armenia Luca Carioti Fabio Continenza Domenico Di Carlo Patrizia Saccomandi Carmen Mirabelli Michela Pollicita Roberta Longo Sara Romano Giuseppina Cappiello Alberto Spanò Pascale Trimoulet Herve Fleury Jacopo Vecchiet Nerio Iapadre Angelo Barlattani Ada Bertoli Terenzio Mari Caterina Pasquazzi Gabriele Missale Cesare Sarrecchia Elisa Orecchini Alessandro Michienzi Massimo Andreoni Simona Francioso Mario Angelico Jens Verheyen Francesca Ceccherini-Silberstein Stephen Locarnini Carlo Federico Perno Valentina Svicher

BACKGROUND An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS This study included 128 chronically HBV-infected patients: 23 with HCC (73.9% D; 26.1% A HBV-genotype), and 105 without cirrhosis/HCC (72....

2014
Fung-Yu Huang Danny Ka-Ho Wong Wai-Kay Seto An-Ye Zhang Cheuk-Kwong Lee Che-Kit Lin James Fung Ching-Lung Lai Man-Fung Yuen

BACKGROUND The underlying mechanism of HBsAg-negative hepatitis B virus (HBV) infection is notoriously difficult to elucidate because of the extremely low DNA levels which define the condition. We used a highly efficient amplification method to overcome this obstacle and achieved our aim which was to identify specific mutations or sequence variations associated with this entity. METHODS A tot...

Journal: :Archives of Iranian medicine 2013
Abolfazl Khedive Ismail Sanei-Moghaddam Seyed Moayed Alavian Esmail Saberfar Mehdi Norouzi MohamadAli Judaki Shiva Ghamari Seyed Mohammad Jazayeri

BACKGROUND Hepatitis B virus (HBV) gene and protein variations have frequently been observed in chronic patients. The aims of this study were to determine the genotypes as well as the patterns of HBsAg variations in chronically-infected patients from the south-eastern part of Iran. METHODS Twenty- one chronic inactive HBV carriers from Sistan-Balouchestan Province (an area with a low prevalen...

Journal: :Annals of hepatology 2014
Pin-Nan Cheng Yen-Cheng Chiu Hung-Wen Tsai Ru-Hsueh Wang Hung-Chih Chiu I-Chin Wu Ting-Tsung Chang

INTRODUCTION The intrahepatic hepatitis B surface antigens (HBsAg) expression is related to disease progression of chronic hepatitis B. We examined the features of intrahepatic HBsAg expression. MATERIAL AND METHODS A total of 181 patients with e antigen positive chronic hepatitis B were enrolled. Patterns and semi-quantitative measurement of intrahepatic HBsAg expression were analyzed. The a...

2014
Barbara V. Lago Francisco C. Mello Flavia S. Ribas Fatima Valente Caroline C. Soares Christian Niel Selma A. Gomes

Hepatitis B virus genotype E (HBV/E) is highly prevalent in Western Africa. In this work, 30 HBV/E isolates from HBsAg positive Angolans (staff and visitors of a private hospital in Luanda) were genetically characterized: 16 of them were completely sequenced and the pre-S/S sequences of the remaining 14 were determined. A high proportion (12/30, 40%) of subjects tested positive for both HBsAg a...

Journal: :Journal of virology 1995
R Schirmbeck W Böhm K Ando F V Chisari J Reimann

The efficiency of different vaccination techniques to prime in vivo major histocompatibility complex class I-restricted murine cytotoxic T-lymphocyte (CTL) precursors to hepatitis B virus small surface antigen (HBsAg) was investigated. Mice were immunized either by injection of a low dose of recombinant HBsAg protein preparations (native HBsAg particles or denatured HBsAg monomers) without adju...

2017
Yan Qiao Shanshan Lu Zhihui Xu Xiaodong Li Kai Zhang Yan Liu Li Zhao Rongjuan Chen Lanlan Si Shumei Lin Dongping Xu Jin Li

The study aimed to determine the association of additional N-glycosylation mutations in the major hydrophilic region (MHR) of hepatitis B virus (HBV) S gene with hepatocellular carcinoma (HCC) occurrence in HBsAg/anti-HBs coexistent patients. A total of 288 HBsAg/anti-HBs coexistent patients and 490 single HBsAg-positive patients were enrolled, including 193 with HCC, 433 with chronic hepatitis...

2017
Mikael Gencay Kirsten Hübner Peter Gohl Anja Seffner Michael Weizenegger Dionysios Neofytos Richard Batrla Andreas Woeste Hyon-suk Kim Gaston Westergaard Christine Reinsch Eva Brill Pham Thi Thu Thuy Bui Huu Hoang Mark Sonderup C. Wendy Spearman Stephan Pabinger Jérémie Gautier Giuseppina Brancaccio Massimo Fasano Teresa Santantonio Giovanni B. Gaeta Markus Nauck Wolfgang E. Kaminski

The diversity of the hepatitis B surface antigen (HBsAg) has a significant impact on the performance of diagnostic screening tests and the clinical outcome of hepatitis B infection. Neutralizing or diagnostic antibodies against the HBsAg are directed towards its highly conserved major hydrophilic region (MHR), in particular towards its "a" determinant subdomain. Here, we explored, on a global s...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1983
R A Marciniak J R Wands R R Bruns P S Malchesky Y Nose E Haber

We covalently linked to regenerated cellulose filters a high-affinity monoclonal IgM produced against epitopes that reside on hepatitis B viral surface antigen (HBsAg). Conditions were established whereby as much as 250 micrograms of anti-HBsAg IgM could be linked to 2-4 mg of regenerated cellulose acetate by using cyanogen bromide and trichloro-s-triazine coupling agents. The immunoreactivity ...

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