Using an HPLC procedure, we evaluated > 10 minor hemoglobins (Hbs) in healthy adults, individuals on long-term aspirin therapy, diabetic subjects, and uremic patients. Hb A1c and Hb A1d3 were the most abundant and important minor Hb components, respectively, accounting for 4.10% +/- 0.50% and 3.46% +/- 0.43% of total Hb in 361 healthy subjects. Acetylated Hb A was a potential interferent in the...

Preconception obesity is a strong predictor of glucose intolerance during pregnancy that has the potential to lead to adverse maternal and offspring effects. An increased prevalence of overweight offspring of obese mothers has been reported, despite normal values in an oral glucose tolerance test (OGTT) during pregnancy (1 ). Such findings might reflect effects of the intrauterine milieu, genet...

study confirms the conclusion of Braga et al. (2 ) that the individuality in Hb A1c is limiting the use of outcome-based or populationbased reference limits for test interpretation and will therefore also limit the use of a fixed cutoff value of 48 mmol/mol (6.5% DCCT) for the diagnosis of diabetes for all individuals/patients. The reason for this is that a small change in Hb A1c may indicate a...

We have developed an improved reference measurement method for hemoglobin A1c (Hb A1c) 1 based on liquid chromatography–isotope dilution–tandem mass spectrometry (LC-ID-MS/MS) with traceability to the SI unit. The method has a small measurement uncertainty (MU) and gives results in good agreement with the accuracy-based IFCC reference method. Kaiser et al. (1 ) demonstrated the possibility of u...

Healthcare providers and patients with diabetes evaluate the efficacy of glycemic control by 2 strategies. One strategy involves self-monitoring of blood glucose (SMBG) by patients, with portable meters and continuous blood glucose monitors or sensing devices. Patients use these glucose values for daily decisionmaking to adjust medication doses and/or modify food intake or exercise regimens. Bl...

Healthcare providers and patients with diabetes evaluate the efficacy of glycemic control by 2 strategies. One strategy involves self-monitoring of blood glucose (SMBG) by patients, with portable meters and continuous blood glucose monitors or sensing devices. Patients use these glucose values for daily decisionmaking to adjust medication doses and/or modify food intake or exercise regimens. Bl...

The variation of a biological measurand can be expressed in the units of the measured concentrations or as a percentage of the absolute variation relative to the mean concentration. For example, given that different metrologic systems are in use for the measurement of human body temperature, this parameter can be expressed in degrees Celsius (Europe), degrees Fahrenheit (US), or degrees Kelvin ...

OBJECTIVE To further knowledge of diabetes management in family practice. DESIGN Retrospective, observational chart audit study. SETTING Southwestern Ontario. PARTICIPANTS A random sample of non-academic family physicians and a random selection of their patients with type 2 diabetes mellitus. MAIN OUTCOME MEASURES Glycemic control as measured by Hb A1C and adherence to recommendations in clinic...

Abstract Background Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality scientific evidence supporting use these assays varies substantially. An expert committee compiled evidence-based recommendations for analysis diabetes. overall strength were evaluated. draft consensus evaluated by invited reviewers presented public comment. Sug...

Haemoglobin A1c (HbA1c) is used to monitor glycaemic control and predict diabetic complications. Measurement of HbA1c can be interfered by haemoglobin (Hb) variant other Hb derivatives include carbamylated elevated labile A1c. This study determine the percentages type interferences during analysis non- reportable results. a cross-sectional using retrospective data HbA1c. The measured on Biorad ...