UNLABELLED Impaired mitochondrial function is important in obesity and the development of insulin resistance and diabetes. The aim of this study was to identify human adipocyte-derived mitochondrial proteins associated with obesity. Mitochondrial proteins from 20 abdominal omental adipose tissue biopsies (13 obese and 7 control subjects) were separated by anion-exchange chromatography coupled t...

The mitochondrial trifunctional protein (TFP) is a multienzyme complex of the fatty acid beta-oxidation cycle. It is composed of four alpha-subunits (HADHA) harboring long-chain enoyl-CoA hydratase and long-chain L-3-hydroxyacyl-CoA dehydrogenase (LCHAD) and four beta-subunits (HADHB) harboring long-chain 3-ketoacyl-CoA thiolase (LKAT). Mutations in either subunit can result in TFP deficiency w...

The purpose of this study was to investigate the effects high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) on skeletal muscle in Apolipoprotein E knockout (ApoE KO) wild-type (WT) C57BL/6J mice. ApoE KO mice fed with a high-fat diet were randomly allocated into: Control group without exercise (ApoE−/− CON), HIIT HIIT), MICT MICT). Exercise endurance, blood lipid p...

Benzene is a well-known hematotoxic carcinogen that can cause leukemia and a variety of blood disorders. Our previous study indicated that benzene disturbs levels of metabolites in the fatty acid β-oxidation (FAO) pathway, which is crucial for the maintenance and function of hematopoietic and leukemic cells. The present research aims to investigate the effects of benzene on changes in the expre...

OBJECTIVE Candidate genes for non-alcoholic fatty liver disease (NAFLD) identified by a bioinformatics approach were examined for variant associations to quantitative traits of NAFLD-related phenotypes. RESEARCH DESIGN AND METHODS By integrating public database text mining, trans-organism protein-protein interaction transferal, and information on liver protein expression a protein-protein int...

In recent decades, per- and polyfluoroalkyl substances (PFASs) have garnered widespread public attention due to their persistence in the environment detrimental effects on health of living organisms, spurring generation several transcriptome-centered investigations understand biological basis mechanism. this study, we collected 2144 publicly available samples from seven distinct animal species ...

To conduct ex-situ creole pig conservation programs, it is essential to determine which breeding animals will be used, preferentially those with a more significant Iberian genetic component preserve their origin. This study used Yucatan black hairless pigs (YBHP) subpopulation estimate its diversity and population structure. One hundred four adult were selected for the absence of hair, skin (wi...