Objectives: Lymph node dissection (LND) in gynecological malignancies has always been a cornerstone the diagnosis of metastasis, it is also considered an important prognostic factor, and reliable guide to management strategies. However, its incidence complications, namely lymphedema, vascular injuries other lesions, led reconsideration efficacy comparison role systematic vs. sentinel lymph (SLN...

Oncological treatment results in a series of major adverse effects, local and systemic, depending on the type of treatment – surgery, radiotherapy (RT), chemotherapy (CT) or a combination of those. Chemotherapy acts mainly systemically, but drugs used during treatment are eliminated through the urinary tract, often unmetabolized, and come in direct contact with the epithelium of the bladder, ur...

This paper encourages understanding a non-invasive technology—the “Liquid biopsy”, including circulating tumor cells (CTCs) and DNA (ct DNA) technology, that can help diagnose early cancers, cancer relapse, resistance to chemotherapy. reviews various CTCs ct studies in the literature about their applications gynecological cancers. Hopefully, further translational research gynecology will enable...

Background: Primary vaginal cancer is uncommon gynecological cancer though epiology is similar to cervical cancer, which is very common in this part of the world. However, vaginal cancer occurs mostly in elderly women. Objective: Analytical study was carried out to know trends, presentation, and stage at diagnosis of vaginal cancer in women from low resource settings. Materials and Methods: Vag...

Gynecologic cancers are the unregulated growth of neoplastic cells that arise in the cervix, ovaries, fallopian tubes, uterus, vagina, and vulva. Although gynecologic cancers are characterized by different signs and symptoms, studies have shown that they share common risk factors, such as smoking, obesity, age, exposure to certain chemicals, infection with human immunodeficiency virus (HIV), an...

BARD1 is required for protein stability and tumor suppressor functions of BRCA1, which depend on the ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. The NH(2)-terminal RING domains of both proteins act as interaction modules and form a ubiquitin ligase, which has functions in DNA repair, cell cycle checkpoint regulation, and mitosis. Interestingly, up-regulated expression of truncated...

Objective: An important factor in the protection of women from gynecological cancers is awareness. Increasing awareness cancer terms early diagnosis disease, treatment and reduction mortality. The research was conducted to determine reproductive age postmenopausal period. Methods: study, designed as a descriptive cross-sectional type, with who were admitted state hospital Çankırı between Octobe...

Grief and hope are two conflicting emotions that a patient recently diagnosed with cancer has to master. The real challenge for gynecologic oncologists is how to reach out. Conventional wisdom states that offering patients focus and belief when combating cancer in their lives allows them to embrace hope with greater confidence, which minimizes their grief. Three pictorial models are presented: ...

BACKGROUND The presence of autoantibodies (AAbs) is the primary serological indicator of autoimmunity. Cancer-associated retinopathy (CAR) is associated with AAbs and different types of cancer. The goal of the study was to examine the profile of serum autoantibodies in women with gynecological cancers with and without paraneoplastic visual manifestation. METHODS Retrospective studies of a coh...

Background: Breast and Gynecological cancers are a major public health problem. Smoking is a lifestyle associated with several chronic diseases including cancer, and is a cause of preventable death. Other lifestyles of public health concern like poor dietary habits and lack of exercise, predisposes many people to dyslipidemia, hypertension and obesity; which are risk factors for metabolic syndr...