Studies have been made of the nuclear magnetic resonance spectra of several allylic Grignard reagents. The Grignard reagent prepared from y,y-dimethylallyl bromide appears best formulated as an equilibrium mixture of y,y-dimethylallylmagnesium bromide and qcx-dimethylallylmagnesium bromide, in which the former is the major component. The rate of interconversion of the allylic isomers is rapid o...

A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.

The addition of Grignard reagents or organolithium reagents to the SO2-surrogate DABSO generates a diverse set of metal sulfinates, suitable for direct conversion to sulfone products. The metal sulfinates can be trapped in situ with a wide range of C-electrophiles, including alkyl, allyl, and benzyl halides, epoxides, and (hetero)aryliodoniums.

Thermal epimerization is the key to changing the endo-to-exo ratio of the diastereomeric bornyl and fenchyl Grignard reagents from 67:33 to 96:4 and from 20:80 to 80:20, respectively.

C functionalization of graphene significantly broadens its application potential via tuning its electronic and surface properties. Therefore, a wide range of dry and wet chemistry approaches have been developed for graphene functionalization. Despite recent progress in this field, covalent modification of graphene is still hampered by its low reactivity. Moreover, the reactivity depends on the ...

A new ligand, Cp*CH2PPh2 (Cp* = 1,2,3,4,5-pentamethyl-2,4-cyclopentadienyl), was prepared, and was used as a ligand for nickel-catalysed cross-coupling reaction of alkyl halides with aryl Grignard reagents, which nickel-phosphine complexes had never made possible.

Herein we disclose an iron-catalyzed cross-coupling reaction of propargyl ethers with Grignard reagents. The was demonstrated to be stereospecific and allows for a facile preparation optically active allenes via efficient chirality transfer. Various tri- tetrasubstituted fluoroalkyl can obtained in good excellent yields. In addition, reagents α-alkynyl oxetanes tetrahydrofurans is disclosed her...

A highly regioselective and enantioselective copper-catalyzed 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones was developed. The 1,4-addition products were obtained regioselectively in high yields with up to 98% ee.

An efficient and highly enantioselective copper-catalyzed allylic alkylation of phosphonates and phosphine oxides with Grignard reagents and Taniaphos or phosphoramidites as chiral ligands is reported. Transformation of these products leads to a variety of new phosphorus-containing chiral intermediates.