Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in v...

Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitis...

Gold nanoparticles have unique optical properties such as surface-plasmon and photothermal effects. Such properties have resulted in gold nanoparticles having several clinical applications. Gold nanorods (which are rod-shaped gold nanoparticles) show a surface plasmon band in the near-infrared region. They have therefore been proposed as contrast agents for bioimaging, or as heating devices for...

in this study, the biosynthesis of gold nanoparticles by penicillium chrysogenum, isolated from ahar copper mine, was investigated. the gold nanoparticles were synthesized by reducing the aqueous gold ions using the culture supernatant of the filamentous fungi. the uv–vis spectrum displayed a characteristic peak at 532 nm that is very specific for gold nanoparticles. the xrd spectrum confirmed ...

background: radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. material and methods: in this study...

The purpose of this study was to evaluate proton depth dose perturbation caused by a radio-opaque hydrogel fiducial marker. Electronic proton stopping powers in the hydrogel were calculated for energies 0.5-250 MeV, and Monte Carlo simulations were generated of hydrogel vs. gold markers placed at various water phantom depths in a generic proton beam. Across the studied energy range, the gel/wat...

Gold nanoparticles have received wide interest in disease diagnosis and therapy, but one of the important issues is their toxicological effects in vivo. Sex differences in the toxicity of gold nanoparticles are not clear. In this work, body weight, organ weight, hematology, and biochemistry were used to evaluate sex differences in immune response and liver and kidney damage. Pathology was used ...

A new optical trapping design to transport gold nanoparticles using a PANDA ring resonator system is proposed. Intense optical fields in the form of dark solitons controlled by Gaussian pulses are used to trap and transport nanoscopic volumes of matter to the desired destination via an optical waveguide. Theoretically, the gradient and scattering forces are responsible for this trapping phenome...

mediciNe & HealtH/RHode iSlaNd partICleS Can be engIneered to nanometer-size (nm) which are only 1/1,000 the width of a single human hair. Nanoparticles made of gold display strong optical absorption. A special type of gold nanoparticle called hollow gold nanoparticle has a core-shell nanostructure with unique characteristics, including small particle size (~40 nm in diameter), which is an idea...