BACKGROUND Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP), and to assess its relationship with familiar environment measured using the Family Environment Scale (FES). METHODS We included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant status, ...

The UCSD Performance-based Skills Assessment (UPSA) is a measure of Functional Capacity and assesses skills involved in community tasks. It has good psychometrics properties, and is currently recommended as a co-primary assessment of cognition in the MATRICS Project. To our knowledge so far, there are no studies in western developing countries concerning Functional Capacity in Schizophrenia. Th...

background: psycho-education is now considered as part of the integrated treatment for bipolar disorder. this study aimed to determine the efficacy of group psycho-education on medication adherence and global functioning of patients with bipolar disorder type i. methods: 45 patients with bipolar disorder type i were allocated one of the three groups of psycho-education plus pharmacotherapy, pha...

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) has dropped the multiaxial diagnostic system and moved to a dimensional system of diagnostic classification. This change means that there is no longer a separate Axis V or specific diagnostic category for assessment of functioning. In addition, the Global Assessment of Functioning Scale (GAF), the previously endors...

Clear links between temperament, psychopathology, and neuropsychological functioning exist; however the interrelations among temperament and neuropsychology, and their impact on functioning in typically developing children is not as well understood. This study examined the degree to which neuropsychological functioning, as measured by the NEPSY, moderates the impact of temperament on global fun...

A recent meta-analysis showed that long-acting injectable (LAI) antipsychotics were not superior to oral antipsychotics for preventing relapse in patients with schizophrenia. We therefore designed a treatment strategy combining risperidone LAI and COMPASS (COMprehensive Psycho-educational Approach and Scheme Set), an original psychoeducational program supporting treatment with risperidone LAI a...

The purpose of this study was to investigate whether the degree of insight into illness is associated with long-term inpatient treatment outcome in chronic schizophrenia. Inpatients diagnosed with schizophrenia were evaluated using the Global Assessment of Functioning (GAF) scale and the Functional Skills Rating Form (FSRF) at baseline and at follow-up evaluation 1 year after treatment. The Sca...

The goal of this study is to explore neurocognitive, clinical and community functioning variables in order to predict "social reasoning" in a sample of patients with a diagnosis of schizophrenic disorder. Cognitive and community functioning, and social reasoning have been evaluated, together with the Positive and Negative Syndromes Scale (PANSS) and DSM-IV Global Assessment of Functioning (GAF)...