Background: In developing countries, there is no doubt that acute kidney injury and chronic liver diseases have a major impact on health. Different venom components are gaining renewed interest as potential sources of new pharmacological compounds relevant for human therapeutics. Aim: The present study was designed to evaluate the therapeutic efficacy crude extract Egyptian spitting cobra (Naja...

Critically ill populations often have shown subtherapeutic aminoglycosides’ concentrations mostly because of unavoidable changes in drug volume distribution and clearance. We present a real life prospective study evaluating plasma for once-daily dosing amikacin gentamycin among population severe burn adults. conducted on the observed patients, using aminoglycoside as combination therapy. Antibi...

BACKGROUND Neonatal sepsis is one of the major causes of morbidity and mortality among the newborns in the developing world. OBJECTIVES To determine the common bacterial isolates causing sepsis in neonatal intensive care unit and its antibiotic susceptibility pattern. METHODS A one year discriptive prospective study was conducted in neonatal intensive care unit to analyse the results of blo...

Although percutaneous titanium implants have become one of the best choices as retainers in the facial defects, peri-implantitis still occurs at a significant rate. This unwanted complication occurs due to adhesion of bacteria and subsequent biofilm formation. To solve this problem, we have developed a novel antibiotic nanodelivery system based on self-decomposable silica nanoparticles. In this...

Chickens recover auditory function after hair cell loss caused by ototoxic drug damage or acoustic overstimulation, indicating that mechanisms exist to reestablish appropriate neuronal connections to regenerated hair cells. However, despite similar hair cell regeneration times, hearing recovery takes substantially longer after aminoglycoside than after sound damage. We have therefore begun exam...

INTRODUCTION Isolation of common pathogens involved in ocular infection, and their in-vitro susceptibility to commonly-used ocular antibiotics, as well as the trends in antibiotic resistance developed by these pathogens, were investigated. METHODS Corneal scrapings were obtained from 318 hospitalised patients and inoculated directly onto enriched and differential culture media. Subcultures we...

In this study, the authors evaluated parenteral treatment of zebu cattle, with naturally and experimentally induced bovine dermatophilosis, in western Sudan, using four different antibiotic treatments. In terms of recovery rate, weight gain, avoiding relapse and preventing death, gentamycin was found to be the most effective treatment, followed by a combination of penicillin and streptomycin an...

UNLABELLED The AIM of this study was to test if L-N-acetylcysteine (L-NAC) can protect hair cells against gentamycin-induced damage in vitro. Mammalian auditory cells are unable to regenerate when affected by several toxic agents. Aminoglycosides are large-scale antibiotics, extremely useful for the treatment of several Gram-negative bacterial infections, but their use is limited by the extreme...