BACKGROUND: Toxocara canis is the most prevalent intestinal roundworm of canid species. OBJECTIVES: This study aims to evaluate the effects of Toxocara canis excretory-secretory antigens (TcES Ag) on modulating the immune system in Experimental Allergic Encephalomyelitis (EAE) model. METHODS: Adult worms of T.canis were collected from dogs to obtain excretory-secretory antigens. Female C57BL/6m...

The Effect of Drought Stresses, Fusarium Culmorum and Heterodera Filipjevi their Interactions on the Expression Pattern Transcription Factor Gene NAC69-3 in Bread Wheat

this study was done to gain insights into transcriptional regulation of negative energy balance (neb) assoctiated genes. overexpressed genes in neb were identified using microarray and rna-seq data and promoter analysis of these overexpressed genes was applied to identify novel transcription factors. moreever, string database was used to construct a regulatory network of identified transcriptio...

Background: Transcription factors (TFs) play a key role in the development, therapy, and relapse of B-cell malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Given the essential function of Forkhead box protein P1 (FOXP1) transcription factor in the early development of B-cells, this study was designed to evaluate FOXP1 gene expression levels in pediatric BCP-ALL pat...

four exons of the human genomic gm-csf gene were assembled together using gene splicing by overlap extension (soe) method. the resulting nucleotide sequence was cloned in the pet23a(+) ex pression vector under the control of strong bacteriophage t7 transcription and translation signals. the construct obtained was transferred into the e. coli strain, bl21(de3) plyss and iptg was used for inducti...

Manipulation of stress related transcription factors to improve plant stress tolerance is a major goal of current biotechnology researches. MYC2 gene encodes a key stress-related transcription factor involved in Jasmonate (JA) and abscisic acid (ABA) signaling pathways in Arabidopsis. Brassica napus, as a globally important oilseed crop, is a close relative of Arabidopsis.  In the present study...

rice plants are injured at the seedling stage in early spring in northern iran. in order to study rice response to cold stress, the expression of osdreb1a, osap37, osmyb3r-2, and osnac6 genes encoding transcription factors was observed in 14-day-old seedlings of cold-tolerant genotype pr and cold-sensitive cv. hashemi during cold stress (5°c for 24 h) using the differential display method and t...

background: pomegranate fruit (punica granatum l.) is a rich source of anthocyanin pigments resulting in vibrant colours and anti-oxidant contents. although the intensity and pattern of anthocyanin biosynthesis in fruit are strongly influenced by r2r3-myb transcription factors, little is known about the regulation and role of myb in anthocyanin pathway of pomegranate.objectives: the present stu...