background: the present study has been carried out to investigate the effects of preovulatory stage gamma-irradiation of female mice in the absence or presence of vitamin e on numerical chromosome abnormalities in 8-cell embryos after mating with non-irradiated males. materials and methods: the 8-11 weeks adult female nmri mice were whole body irradiated at preovulatory stage (post pmsg injecti...

Abstract A leaky gut has been linked to numerous autoimmune disorders, including systemic lupus erythematosus (SLE). We had previously reported significant upregulation of anti-flagellin antibodies in the blood SLE patients and lupus-prone MRL/lpr mice, which led our hypothesis that a drove through bacterial flagellin-mediated activation toll-like receptor 5 (TLR5). Here, we investigated initia...

Background: Whenever the balance between Antioxidants and reactive oxygen species (ROS) is disrupted towards an overabundance of ROS, oxidative stress (OS) occurs. There is evidence that glutathione as an intracellular antioxidant plays an important role against ROS in female reproductive system. BSO is a selective inhibitor of glutathione peroxidas. The aim of the present study is to investiga...

Background: Due to different such as some sexrelated illnesses, spouses have been encourage to designate special treatments for assessing sexuality. Moreover, Utilizing from identifying sexulityb has been an important aim in industry in order to product humans needs and develop cattle. In this research, the effect of alkaline environments were examined migration spermatozoa for sex selection. M...

Background: Antioxidants and reactive oxygen species (ROS) are in balance in the body. Whenever the balance between these molecules is disrupted towards an overabundance of ROS, oxidative stress (OS) occurs. There are evidence that glutathione as an intracellular antioxidant plays an important role against ROS in female reproductive system. Regarding the effect of BSO as a selective inhibitor o...

background: phenol is an estrogenic and toxic compound and people are widely exposed to it, in different ways.  objectives: the aim of this study was to determine  the  negative effects of phenol on the fertility of male mice, by investigating sperm parameters including viability, motility, fertility rates and daily sperm production (dsp). methods: a total of 106 adult nih mice were divided int...

the acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. for subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. the intraperitoneal ld50 values of safranal were 1.48 ml/kg in male mice, 1.88 ml/kg in female mice and 1.50 ml/kg in male rats. oral ld50 values were ...