نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

2009
N. Y. Mohd-Yusof O. Monroig A. Mohd-Adnan

Lates calcarifer, commonly known as the Asian sea bass or barramundi, is an 16 interesting species that has great aquaculture potential in Asia including Malaysia and also 17 Australia. We have investigated essential fatty acid metabolism in this species, focusing on 18 the endogenous highly unsaturated fatty acid (HUFA) synthesis pathway using both 19 biochemical and molecular biological appro...

Journal: :Hypertension 2012
Vanessa A Mackay Shahzya S Huda Frances M Stewart Kahmeng Tham Louise A McKenna Iain Martin Fiona Jordan E Ann Brown Leanne Hodson Ian A Greer Barbara J Meyer Dilys J Freeman

Obesity and excessive lipolysis are implicated in preeclampsia (PE). Intrauterine growth restriction is associated with low maternal body mass index and decreased lipolysis. Our aim was to assess how maternal and offspring fatty acid metabolism is altered in mothers in the third trimester of pregnancy with PE (n=62) or intrauterine growth restriction (n=23) compared with healthy pregnancies (n=...

2017
Noriko Ishihara Sawako Suzuki Shou Tanaka Yasuhiro Watanabe Daiji Nagayama Atsuhito Saiki Tomoaki Tanaka Ichiro Tatsuno

Numerous clinical studies have reported that statins increase the plasma concentration of arachidonic acid, which is an ω-6 long-chain polyunsaturated fatty acid (LCPUFA), and decrease the concentrations of eicosapentaenoic acid and docosahexaenoic acid, which are ω‑3 LCPUFAs. These findings indicate that statins may affect the endogenous synthesis of LCPUFAs, which is regulated by fatty acid d...

2016
Marte Avranden Kjær Bente Ruyter Gerd Marit Berge Yajing Sun Tone-Kari Knutsdatter Østbye

Limited availability of the n-3 fatty acids EPA and DHA have led to an interest in better understanding of the n-3 biosynthetic pathway and its regulation. The biosynthesis of alpha-linolenic acid to EPA and DHA involves several complex reaction steps including desaturation-, elongation- and peroxisomal beta-oxidation enzymes. The aims of the present experiments were to gain more knowledge on h...

2013
Xiaoqin Sun Hui Pang Mimi Li Bin Peng Haisong Guo Qinqin Yan Yueyu Hang

The fatty acid elongase 1 (FAE1) gene catalyzes the initial condensation step in the elongation pathway of VLCFA (very long chain fatty acid) biosynthesis and is thus a key gene in erucic acid biosynthesis. Based on a worldwide collection of 62 accessions representing 14 tribes, 31 genera, 51 species, 4 subspecies and 7 varieties, we conducted a phylogenetic reconstruction and correlation analy...

2013
Hyun Uk Kim Su-Jin Jung Kyeong-Ryeol Lee Eun Ha Kim Sang-Min Lee Kyung Hee Roh Jong-Bum Kim

The LEAFY COTYLEDON2 (LEC2) gene plays critically important regulatory roles during both early and late embryonic development. Here, we report the identification of the LEC2 gene from the castor bean plant (Ricinus communis), and characterize the effects of its overexpression on gene regulation and lipid metabolism in transgenic Arabidopsis plants. LEC2 exists as a single-copy gene in castor be...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
F Beaudoin L V Michaelson S J Hey M J Lewis P R Shewry O Sayanova J A Napier

A Caenorhabditis elegans ORF encoding the presumptive condensing enzyme activity of a fatty acid elongase has been characterized functionally by heterologous expression in yeast. This ORF (F56H11. 4) shows low similarity to Saccharomyces cerevisiae genes involved in fatty acid elongation. The substrate specificity of the C. elegans enzyme indicated a preference for Delta(6)-desaturated C18 poly...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2015
Alexis Varin Charles Thomas Minako Ishibashi Louise Ménégaut Thomas Gautier Amalia Trousson Victoria Bergas Jean Paul Pais de Barros Michel Narce Jean Marc A Lobaccaro Laurent Lagrost David Masson

OBJECTIVE Liver X receptors (LXRs) modulate cholesterol and fatty acid homeostasis as well as inflammation. This study aims to decipher the role of LXRs in the regulation of polyunsaturated fatty acid (PUFA) synthesis in macrophages in the context of atherosclerosis. APPROACH AND RESULTS Transcriptomic analysis in human monocytes and macrophages was used to identify putative LXR target genes ...

Journal: :Journal of cell science 2007
Anita Jung Martin Hollmann Mireille A Schäfer

The essential gene noa (CG 3971; also known as Baldspot) encodes a very long chain fatty acid elongase which is most similar to the mammalian elongase ELOVL6. noa is expressed in the nervous system from embryogenesis on, in imaginal discs, the fat body, malpighian tubules and in the gonads of both sexes. Its function is dose dependent, since reduced levels of noa RNA lead to impaired motility a...

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