نتایج جستجو برای: e4

تعداد نتایج: 3623  

Journal: :Genetics and molecular research : GMR 2015
Q Chen X D Peng C Q Huang X Y Hu X M Zhang

In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD). This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively. A total of 296 unrelated AD patients and 423 control subject...

2006
Christian R.A. Mondadori Dominique J.-F. de Quervain Andreas Buchmann Henrietta Mustovic M. Axel Wollmer Conny F. Schmidt Peter Boesiger Christoph Hock Roger M. Nitsch Andreas Papassotiropoulos Katharina Henke

The apolipoprotein E (APOE) e4 allele is the major genetic risk factor for Alzheimer’s disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown. We found an association of APOE e4 with better episodic memory compared with APOE e2 and e3 in 340 young, healthy persons. Neuroimaging was performed in a subset of 34 memory-matched ind...

Journal: :Alcohol and alcoholism 2014
Brian Downer Faika Zanjani David W Fardo

AIMS The aim of the study was to determine whether the trajectory of learning and memory is modified according to an interaction between midlife or late life alcohol consumption status and the presence of one or more APOE e4 alleles. METHODS This was a secondary analysis of cognitive, genetic and alcohol consumption data collected from members of the Framingham Heart Study Offspring Cohort. ...

2005
Adam Fleisher Hyun T. Kim Denise H. B. Schiller Myron F. Weiner Leon J. Thal

Design: This study evaluated MCI in 193 subjects (86 women and 107 men) participating in a multicenter clinical trial, all of whom underwent magnetic resonance imaging at their baseline visit. We evaluated the association among the number of APOE*E4 alleles, memory performance, and hippocampal volume in men and women with tests of means and multiple linear regressions. Results: Compared with MC...

Journal: :Journal of virology 2005
Clare E Davy Deborah J Jackson Kenneth Raj Woei Ling Peh Shirley A Southern Papia Das Rina Sorathia Peter Laskey Kate Middleton Tomomi Nakahara Qian Wang Phillip J Masterson Paul F Lambert Scott Cuthill Jonathan B A Millar John Doorbar

Human papillomavirus type 16 (HPV16) can cause cervical cancer. Expression of the viral E1 E4 protein is lost during malignant progression, but in premalignant lesions, E1 E4 is abundant in cells supporting viral DNA amplification. Expression of 16E1 E4 in cell culture causes G2 cell cycle arrest. Here we show that unlike many other G2 arrest mechanisms, 16E1 E4 does not inhibit the kinase acti...

Journal: :European journal of biochemistry 1993
J C Schittny C M Schittny

Laminin self-assembles into a basement membrane polymer through specific low-affinity interactions. Recently, it was shown that the terminal short-arm domain (domains VI and V) of the B1 chain (fragment E4) possesses one of the laminin self-interaction sites [Schittny, J.C. & Yurchenco, P.D. (1990) J. Cell Biol. 110, 825-832], but that the binding partner(s) of this domain is unknown. Using aff...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 2001
D G Blazer G Fillenbaum B Burchett

BACKGROUND Given previous findings of adverse health outcomes associated with the E4 allele, data from a biracial community sample of older adults were used to determine whether functional decline is associated with the apolipoprotein E (APOE) E4 allele. METHODS In 1986, a stratified random household sample of community residents 65 years of age and older (n = 4162) formed the Duke Establishe...

2016
Ekaterine Tskitishvili Christel Pequeux Carine Munaut Renaud Viellevoye Michelle Nisolle Agnes Noël Jean-Michel Foidart

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/proliferating effects of E4 on H2O2-induced ...

Journal: :Discussiones Mathematicae Graph Theory 2010
Manju K. Menon Ambat Vijayakumar

The edge C4 graph of a graph G, E4(G) is a graph whose vertices are the edges of G and two vertices in E4(G) are adjacent if the corresponding edges in G are either incident or are opposite edges of some C4. In this paper, we show that there exist infinitely many pairs of non isomorphic graphs whose edge C4 graphs are isomorphic. We study the relationship between the diameter, radius and domina...

Journal: :Cancer research 1975
M S Paranjpe C W Boone

A momogenate of an SV40-transformed firbosarcoma of BALB/c mice (E4 tumor) injected i.p. into E4, tumor-immune syngeneic mice specifically depressed their cell-mediated immune responses to autologous tumor cells, as measured by a radioisotopic foot pad assay. The fraction of the tumor homogenate that brought about this depression was present in the high-speed supernatant and pellet of a 3 M KCl...

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