The transcription factors encoded by the E2A and early B cell factor ( EBF ) genes are required for the proper development of B lymphocytes. However, the absence of B lineage cells in E2A and EBF -deficient mice has made it difficult to determine the function or relationship between these proteins. We report the identification of a novel model system in which the role of E2A and EBF in the regu...

The time of origin, development, and morphology of neurons originating before the establishment of the cortical plate (preplate cells) were studied in the telencephalic vesicle of the rat from the embryonic day 10 (E10) to E15. The first postmitotic neurons settle superficial to the ventricular zone in the preplate at E12. We have observed mitotic figures in the preplate at E12 and E13, and reg...

Helicobacter pylori colonises the gastric mucosa of humans. The majority of organisms live in mucus. These organisms are an important reservoir for infection of the underlying epithelium. Cell culture models for H. pylori infection do not normally possess a mucus layer. The interaction of H. pylori with TFF1, a member of the trefoil factor family found in gastric mucin, is mediated by lipopolys...

A finite element analysis of intergranular normal stresses is performed in order to identify a possible statistical correlation between the and corresponding grain boundary type within polycrystalline aggregate. Elastic continuum grains cubic lattice symmetry are assumed analysis. Meaningful results obtained by analyzing first two moments on several types. Among five macroscopic parameters (5D)...

By sampling perturbed state vectors from each ensemble forecast at additional time levels shifted by ±τ (where τ is a selected interval) the analysis time, time-expanded (TES) can not only sample timing errors (or phase errors) but also triple size for covariance construction without increasing size. In this study, TES was applied to convection-allowing ensemble-based warn-on-forecast system (W...

The E12 epoxy method of sheet plastination for preparing thin, transparent and serially sectioned cadaveric teaching specimens has been utilised primarily for studying sectional anatomy and correlation of MRI and CT radiographic images. The unique properties of the E12 process offer an exceptionally vivid survey of the human body in any given plane resulting in precise deliniation of the struct...

PURPOSE In this study, we used laser capture microdissection (LCM) and microarray hybridization technology to compare the gene expression profiles of mouse embryonic days 10 and 12 lenses (E10 and E12). METHODS Lens cells of C57/BL6 mouse embryos at E10 and E12 were harvested using the PixCell II LCM System. Total RNA was extracted, amplified, labeled, and hybridized to the 430 2.0 mouse chip...

Hysteresis in a Three-Equation Model by Thomas R. Michl JEL E11, E12, O42

The development of synaptic function was examined at auditory nerve synapses in the rostromedial region of the cochlear nucleus magnocellularis of the chick. EPSCs were studied beginning at embryonic day 12 (E12), when synaptic transmission was first observed, through E19. The amplitude of evoked EPSCs produced by AMPA receptor (AMPA-R) increased 30-fold over this age range, whereas NMDA recept...

A T-lymphocyte-specific enhancer located 13 kb upstream of the murine CD4 gene was recently shown to be required for the developmentally regulated expression of CD4. We have previously identified three nuclear protein binding sites in this enhancer; one of these sites, CD4-3, is essential for expression and contains two E-box core motifs (CANNTG) adjacent to each other in the sequence TAACAGGTG...