نتایج جستجو برای: double strand break

تعداد نتایج: 297026  

Journal: :Journal of cell science 2003
Janet K Jang Dalia E Sherizen Rajal Bhagat Elizabeth A Manheim Kim S McKim

The relationship between synaptonemal complex formation (synapsis) and double-strand break formation (recombination initiation) differs between organisms. Although double-strand break creation is required for normal synapsis in Saccharomyces cerevisiae and the mouse, it is not necessary for synapsis in Drosophila and Caenorhabditis elegans. To investigate the timing of and requirements for doub...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2014
Qin Qin Hong Xie Sandra S Wise Cynthia L Browning Kelsey N Thompson Amie L Holmes John Pierce Wise

The aim of this study was to focus on hexavalent chromium, [Cr(VI)], a chemical carcinogen and major public health concern, and consider its ability to impact DNA double strand break repair. We further focused on particulate Cr(VI), because it is the more potent carcinogenic form of Cr(VI). DNA double strand break repair serves to protect cells against the detrimental effects of DNA double stra...

ژورنال: سنجش و ایمنی پرتو 2020

Radiotherapy using various beams is one of the methods for treating cancer, Hadrons  used   to  treat cancers  that  are  near critical organs. The most important part of the cell that is damage by ionizing radiation is DNA. In this study, damages induced in the  genetic material of  living cells (DNA) defined by  the  atomic model from the  protein data bank (PDB) have been studied by  radiati...

Journal: :Genetics 1997
N K Takahashi K Sakagami K Kusano K Yamamoto H Yoshikura I Kobayashi

Double-strand break repair models of genetic recombination propose that a double-strand break is introduced into an otherwise intact DNA and that the break is then repaired by copying a homologous DNA segment. Evidence for these models has been found among lambdoid phages and during yeast meiosis. In an earlier report, we demonstrated such repair of a preformed double-strand break by the Escher...

Journal: :Genetics 2003
Jason D Merker Margaret Dominska Thomas D Petes

The double-strand break repair (DSBR) model of recombination predicts that heteroduplexes will be formed in regions that flank the double-strand break (DSB) site and that the resulting intermediate is resolved to generate either crossovers or noncrossovers for flanking markers. Previous studies in Saccharomyces cerevisiae, however, failed to detect heteroduplexes on both sides of the DSB site. ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Luther Davis Nancy Maizels

DNA nicks are the most common form of DNA damage, and if unrepaired can give rise to genomic instability. In human cells, nicks are efficiently repaired via the single-strand break repair pathway, but relatively little is known about the fate of nicks not processed by that pathway. Here we show that homology-directed repair (HDR) at nicks occurs via a mechanism distinct from HDR at double-stran...

Journal: :The Journal of biological chemistry 2003
Stephane Vispé Erick L Y Ho Tetsu M C Yung Masahiko S Satoh

Double-strand DNA breaks are the most lethal type of DNA damage induced by ionizing radiations. Previously, we reported that double-strand DNA breaks can be enzymatically produced from two DNA damages located on opposite DNA strands 18 or 30 base pairs apart in a cell-free double-strand DNA break formation assay (Vispé, S., and Satoh, M. S. (2000) J. Biol. Chem. 275, 27386-27392). In the assay ...

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