Measurement of lung volumes at end expiratory level and assessment of ventilation inhomogeneity is important for respiratory management in infants with lung disease. This study compared multiple breath nitrogen washout was compared with body plethysmography to measure functional residual capacity in infants and assessed ventilation inhomogeneity using mean dilution numbers and alveolar based ga...

A linear relationship exists between the quantity of human serum used and the quantity of influenza A virus neutralized. By means of this relationship it is possible to determine the maximum quantity of virus which a given human serum can neutralize. This quantity, the neutralizing capacity, is a fixed value and, unlike the serum dilution end point, is independent of the amount of virus used in...

Clinicians caring for children or adults with pulmonary arterial hypertension (PAH) face a number of challenges, not the least of which is determining whether a patient has met treatment targets based on changes in a given test (such as the 6-min walk distance (6MWD)) and whether these changes translate to meaningful improvements in that patient's quality of life or survival. While several trea...

The variational derivative of a functional J[y] can be defined as δJ/δy = F y (x, y, y ′)− d dx F y ′ (x, y, y ′) [1, pp. 27–29]. Euler's equation essentially states that the variational derivative of the functional must vanish at an extremum. This is analogous to the well-known result from calculus that the derivative of a function must vanish at an extremum. In this section, we consider a sim...

Infrared oculography was performed during sustained lateral gaze in 12 normal subjects to investigate end-point nystagmus while fixating a target light. Five failed to develop nystagmus despite deviation up to 40 degrees from 4 to 5 min. Six subjects developed nystagmus immediately or shortly after reaching the deviated position. In one, the nystagmus (0.5 degrees to 1 degree and 1.0 Hz) began ...

Envelope antigens of the Mason-Pfizer monkey virus (MPMV) and the morphologically similar HeLa virus, which is continuously produced in some HeLa cell lines, were compared by indirect immunoferritin techniques. Antisera raised against MPMV and HeLa virus revealed cross-reacting antigenic specificities on the surfaces of both agents, and cross-absorption and end-point dilution techniques indicat...

Streptovaricin' is a complex of closely related antibiotics which has received extensive study in our laboratories because of its broad in vitro antibacterial spectrum, and its in vivo activity against experimental infections of mice and guinea pigs with virulent strains of Mycobacterium tuberculosis (Siminoff et al., 1957; Whitfield et al., 1957; Rhuland et al., 1957). A number of interesting ...