For more than 100 years, neuromyelitis optica (NMO), known as Devic disease, was thought to be a variant of multiple sclerosis (MS), despite observations that acute episodes were restricted to the optic nerve and spinal cord and were more immediately devastating than in MS. It was not until 1999—when neurologists and MS specialists Brian G. Weinshenker, MD, at Mayo Clinic in Rochester, Minnesot...

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