Dermal sinuses are well-characterized lesions (1-3). A patient with a dermal sinus frequently has a hairy nevus or dimple overlying the tract. Yet, despite having this cutaneous marker, these patients often seek medical attention only after they suffer an infectious complication of the tract. Although infection most commonly will occur in the form of a cutaneous abscess, another more serious an...

Although dermal fibroblasts are one of the first cell types exposed to West Nile virus (WNV) during a blood meal by an infected mosquito, little is known about WNV replication within this cell type. Here, we demonstrate that neuroinvasive, WNV-New York (WNV-NY), and nonneuroinvasive, WNV-Australia (WNV-AUS60) strains are able to infect and replicate in primary human dermal fibroblasts (HDFs). H...

Innate resistance to Candida albicans in mucosal tissues requires the production of interleukin-17A (IL-17A) by tissue-resident cells early during infection, but the mechanism of cytokine production has not been precisely defined. In the skin, we found that dermal γδ T cells were the dominant source of IL-17A during C. albicans infection and were required for pathogen resistance. Induction of I...

Dermal melanocytic disorders present as bluish pigmentation on the skin. Several entities including Mongolian spot, aberrant nevus of Ota, and Ito have been reported. It is often difficult to distinguish between different from their overlapping features. Although they share similar etiologies histologic findings, co-morbidities prognosis differ. In this paper, we report four cases dermal which ...

Leishmania siamensis infection was recently reported from Thailand. Clinical presentation of L. siamensis infections is generally related to human immunodeficiency virus infection. Herein, disseminated dermal L. siamensis infection in a systemic steroid therapy patient from Myanmar is described.

Responsive, theranostic nanosystems, capable of both signaling and treating wound infections, is a sophisticated approach to reduce the most common and potentially traumatizing side effects of burn wound treatment: slowed wound healing due to prophylactic anti-infective drug exposure as well as frequent painful dressing changes. Antimicrobials as well as dye molecules have been incorporated int...

The objective was to study Dupuytren's myofibroblast cells in constrained collagen matrices in order to more closely emulate their in vivo environment and, to correlate their contractility with alpha-smooth muscle actin (alpha-SMA) expression and determine if dermal fibroblasts regulate Dupuytren's myofibroblast phenotype. Isotonic and isometric force contraction by cells isolated from Dupuytre...

BACKGROUND Acellular dermal matrix has been increasingly accepted in prosthetic breast reconstruction. Observed benefits include improved control and support of implant position, better implant coverage, and the suggestion of a decreased capsular contracture rate. Based on this positive experience, it is not surprising that acellular dermal matrix would be applied to other challenging implant-r...

1 Hiroshi Matsumoto, MD Yoshihiro Kimata, MD, PhD Seiji Komatsu, MD, PhD Kumiko Matsumoto, MD Min Zaw Aung, MBBS, MMedSc (Surgery) Department of Plastic and Reconstructive Surgery Graduate School of Medicine, Dentistry, and Pharmaceutical Science University of Okayama Okayama, Japan Sir: W performing dermal sutures, we aim to achieve a satisfactory postoperative scar from an aesthetic perspecti...