SUGAMMADEX IS BELONGING TO A NEW CLASS OF DRUGS the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and the unique ability, for the first time, to reverse rapidly and efficie...

Malignant hyperthermia (MH) may lead to metabolic crisis of skeletal muscle in susceptible individuals following exposure to triggering agents such as volatile anesthetics or depolarizing muscle relaxants. MH is a rare and a potentially lethal disease, which can lead to cardiac arrest. We report a case of severe MH, in which the rapidly evolving signs of hypermetabolism eventually resulted in c...

The potential changes In neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. Org-9426 (rocuronium) and Org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. The problems seen after prolonged administration of muscle relaxants are thought to ari...

The author discusses various procedures for assessing the patient's degree of muscle relaxation utilizing a peripheral nerve stimulator. Based on clinical observation, a preferred method is offered. To obtain the relaxation necessary for certain surgical procedures, the usual technique is to administer a pre-calculated dose of non-depolarizing muscle relaxant. The most common method to calculat...

The next scheduled update for this topic will be December 2003. Introduction 4 Scope and Key Questions 5 Methods 8 Literature Search 8 Study Selection 8 Data Abstraction 9 Quality Assessment 10 Data Synthesis 11 Results 11 Summary 25 References 26 Tables Table 1. Overview of included systematic reviews on skeletal muscle relaxants 38 Table 2. Overview of head-to-head trials of skeletal muscle r...

The effect of carbon dioxide on the neuromuscular blocking effect of the non-depolarizing muscle relaxants tubocurarine and gallamine has been known for some time. Kalow (1954) noted that the action of tubocurarine on an isolated muscle preparation was increased by lowering the pH. Payne (1958) found that in the anaesthetized cat the activity of tubocurarine was increased with a reduction of pH...

The incidence and severity of muscle pain was assessed in 150 males who underwent bronchoscopy using thiopentone and suxamethonium iodide or chloride for anaesthesia. In 50 patients tubocurarine 3-5 mg, diplacin 10-15 mg or kvalidil 10-15 mg was injected intravenously after the induction dose of thiopentone. In a further group of 50 patients neostigmine 0.5-0.75 mg was injected intramuscularly ...

Background Fulminant malignant hyperthermia (MH) is a rare emergency that should be known to every medical professional although practical exposure is a rarity even for experienced anesthesiologists. The vast majority of documented MH cases occurred during general anesthesia in the operating room following application of volatile anesthetics and/or depolarizing muscle relaxants. With increasing...