It is generally accepted that cementoblasts originate in the process of differentiation of the mesenchymal cells of the dental follicle. Recently, a different hypothesis for the origin of cementoblasts has been proposed. Hertwig's epithelial root sheath cells undergo the epithelial-mesenchymal transformation to differentiate into cementoblasts. To elucidate whether the epithelial-mesenchymal tr...

Adult stem cells (ASC) have been found in many tissues and are of great therapeutic potential due to their capability of differentiation. However, ASC comprise only a small fraction of the tissues. In order to use ASC for therapeutic purposes, it is important to obtain relatively pure stem cells in large quantities. Current methods for stem cell purification are mainly based on marker-dependent...

Engineering of craniofacial tissues would have a profound impact on various treatment strategies in dentistry. The role of mesenchymal stem cells in the formation of all craniofacial and dental structures has been well demonstrated. Stem cells from various craniofacial structures like dental epithelium, dental follicle, apical papilla, exfoliated deciduous teeth, periodontal ligament and dental...

PURPOSE To describe the features of impacted upper canines and their relationship with adjacent structures through three-dimensional cone-beam computed tomography (CBCT) images. MATERIALS AND METHODS Using the CBCT scans of 79 upper impacted canines, we evaluated the following parameters: gender, unilateral/bilateral occurrence, location, presence and degree of root resorption of adjacent tee...

In the developing mammalian tooth, the cranial neural crest derived dental mesenchyme consists of the dental papilla and dental follicle. The dental papilla gives rise to odontoblasts and dental pulp and the dental follicle gives rise to the periodontium, including the osteoblasts that contribute to the alveolar process. The alveolar process is a specialized intramembranous bone that forms the ...

background  wisdom teeth are usually removed as a routine procedure for therapeutic or prophylactic reasons. developing wisdom teeth are easy accessible source of stem cells during the adulthood which could be obtained. methods  search of the pubmed for stem cells and tooth was done. an inclusion criterion was extract of stem cells from wisdom tooth. results  stem cells can be obtained from den...

background: human dental stem cells have high proliferative potential for self-renewal that is important to the regenerative capacity of the tissue. objective: the aim was to isolate human dental pulp stem cells (dpsc), periodontal ligament stem cells (pdlsc) and periapical follicle stem cells (pafsc) for their potential role in tissue regeneration. materials and methods: in this experimental s...

Dental trigeminal nerve fiber growth and patterning are strictly integrated with tooth morphogenesis, but it is still unknown, how these two developmental processes are coordinated. Here we show that targeted inactivation of the dental epithelium expressed Fgfr2b results in cessation of the mouse mandibular first molar development at the degenerated cap stage and the failure of the trigeminal m...