Demodex mites colonized the hair follicles and sebaceous glands of mammals millions of years ago and have remained relatively unchanged in this protected ecologic niche since then. The host immune system detects and tolerates their presence. Toll-like receptor-2 of keratinocytes has been demonstrated to recognize mite chitin and to elicit an innate immune response. The subsequent acquired immun...

BACKGROUND There are controversial reports about the role of Demodex mites in pathogenesis of acne rosacea. The aim of this study was to examine the relationship between the presence and number of Demodex mites and the pathogenesis of rosacea. METHODS In this case-control study, the prevalence of Demodex mites was studied in facial biopsy of 75 patients with acne rosacea as case group, and in...

1 Professor de Semiologia e Clínica Médica – FFALM – Bandeirantes – PR e Doutorando do Depto. de Reprodução Veterinária e Radiologia Animal -FMVZ-UNESP/Botucatu – SP. Endereço para correspondência: Hospital Veterinário FFALM, BR 369, Km 54, Cx. Postal: 261, Bandeirantes PR, 86360-000. 2 Faculdade de Medicina Veterinária e Zootecnia (FMVZ) – Universidade Estadual Paulista (Unesp), Distrito de Ru...