نتایج جستجو برای: ctgf

تعداد نتایج: 1816  

2016
Shinichiro Kato Satoru Yokoyama Yoshihiro Hayakawa Luhui Li Yusuke Iwakami Hiroaki Sakurai Ikuo Saiki

Although the secretory matricellular protein connective tissue growth factor (CTGF) has been reported to be related to lung cancer metastasis, the precise mechanism by which CTGF regulates lung cancer metastasis has not been elucidated. In the present study, we show the molecular link between CTGF secretion and the p38 pathway in the invasive and metastatic potential of non-small-cell lung canc...

2012
Tirumuru Nagaraja Li Chen Anuradha Balasubramanian Jerome E. Groopman Kalpana Ghoshal Samson T. Jacob Andrew Leask David R. Brigstock Appakkudal R. Anand Ramesh K. Ganju

BACKGROUND The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the pathogenesis of hepatitis C virus (HCV)-induced liver fibrosis remains unclear. METHODS In the present study, we assessed CTGF expression in HCV-infected hepatocytes using replicon ...

2011
Long Cheng Zhihong Yang Xiaohui Wang Yuanyuan Jiao Xiangyang Xie Jing Lin Hao Zhang Juqiang Han Kai Jiang Qinong Ye

Secreted growth factors have been shown to stimulate the transcriptional activity of estrogen receptors (ER) that are responsible for many biological processes. However, whether these growth factors physically interact with ER remains unclear. Here, we show for the first time that connective tissue growth factor (CTGF) physically and functionally associates with ER. CTGF interacted with ER both...

2012
Jennifer L. Winkler Mamdouh H. Kedees Yelena Guz Gladys Teitelman

PURPOSE Connective tissue growth factor (CTGF) is a profibrotic factor that induces extracellular matrix (ECM) production and angiogenesis, two processes involved in diabetic retinopathy (DR). In this study, we examined whether insulin therapy or a CTGF-specific small interfering RNA (siRNA) administered to diabetic rats decreased the levels of CTGF and of selected putative downstream genes in ...

2013
Yan Zhen Yanfen Ye Xiaoli Yu Chunping Mai Ying Zhou Yan Chen Huiling Yang Xiaoming Lyu Ye Song Qiangyun Wu Qiaofen Fu Mengyang Zhao Shengni Hua Hao Wang Zhen Liu Yajie Zhang Weiyi Fang

BACKGROUND The role of CTGF varies in different types of cancer. The purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN CTGF expression levels were examined in NPC tissues and cells, nasopharynx (NP) tissues, and NP69 cells. The effects and molecular mechanisms of CTGF expression on ce...

Journal: :Endocrinology 2008
Eli Rimon Baosheng Chen Anthony L Shanks D Michael Nelson Yoel Sadovsky

The mechanisms underlying cellular injury when human placental trophoblasts are exposed to hypoxia are unclear. Connective tissue growth factor (CTGF) mediates cell injury and fibrosis in diverse tissues. We hypothesized that hypoxia enhances the production of CTGF in primary term human trophoblasts. Using cultured term primary human trophoblasts as well as villous biopsies from term human plac...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999
M R Duncan K S Frazier S Abramson S Williams H Klapper X Huang G R Grotendorst

Connective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation with transforming growth factor beta (TGF-beta) that acts as a downstream mediator of TGF-beta-induced fibroblast proliferation. We performed in vitro and in vivo studies to determine whether CTGF is also essential for TGF-beta-induced fibroblast collagen synthesis. ...

Journal: :The Journal of biological chemistry 2000
A Hahn J Heusinger-Ribeiro T Lanz S Zenkel M Goppelt-Struebe

Expression of connective tissue growth factor (CTGF) was induced in renal mesangial cells by activation of heptahelical receptors by serotonin (5-HT) and lysophosphatidic acid (LPA). Induction of CTGF mRNA was transient with maximal expression after 1 to 2 h, whereas induction of CTGF by transforming growth factor beta (TGF-beta) increased over time. In contrast to the induction of other early ...

Journal: :Investigative ophthalmology & visual science 2004
Qian Garrett Peng T Khaw Timothy D Blalock Gregory S Schultz Gary R Grotendorst Julie T Daniels

PURPOSE This study was undertaken to investigate the role of connective tissue growth factor (CTGF) in fibroblast-to-myofibroblast differentiation and fibroblast-mediated collagen matrix contraction in the presence of mechanical stress. METHODS An in vitro three-dimensional contraction model of human corneal-fibroblast-seeded collagen lattices (FSCLs) in the presence of mechanical stress gene...

Journal: :Cancer research 2007
Ryoko Kikuchi Hitoshi Tsuda Yae Kanai Takahiro Kasamatsu Kazuo Sengoku Setsuo Hirohashi Johji Inazawa Issei Imoto

Connective tissue growth factor (CTGF) is a secreted protein belonging to the CCN family, members of which are implicated in various biological processes. We identified a homozygous loss of CTGF (6q23.2) in the course of screening a panel of ovarian cancer cell lines for genomic copy number aberrations using in-house array-based comparative genomic hybridization. CTGF mRNA expression was observ...

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