BACKGROUND Innate and adaptive immune responses change with increasing age and affect the course of diseases. Previous study investigated immunologic alteration in Western nasal polyps (NP) which is mostly eosinophilic. However, there are no reports regarding age-related immune changes of non-eosinophilic NP (NE-NP) which is a predominant subtype in Asian population. METHODS A total of 153 su...

We consider the task of constructing interactive proofs for NP which can provide meaningful security for a prover even in the presence of continual memory leakage. We imagine a setting where an adversarial verifier participates in multiple sequential interactive proof executions for a fixed NP statement x. In every execution, the adversarial verifier is additionally allowed to leak a fraction o...

Results MMP-8,9 were the highest among all above MMPs. MMP-8 of NP tissue was much higher than that of CRS and control tissue (P<0.001). MMP-9 of NP tissue was also significantly higher than that of CRSsNP and control tissue (P<0.05). MMP-7 of NP tissue and CRSsNP were much higher than that of control tissue (P<0.001). MMP2 of CRSsNP tissue was much higher than that of NP and control tissue (P<...

Allergic rhinitis (AR), often considered to be a trivial health problem, affects up to 20% of the world population and is the most common chronic disease [1]. The importance of AR lies in the fact that it is predominantly associated with bronchial asthma, a disease which affects 300 million patients worldwide [2]. Furthermore, these patients often have associated sinusitis which is now termed a...

A Phase IIb, randomized, multicenter study of the efficacy of GVAX pancreas vaccine and CRS-207 compared to chemotherapy or to CRS-207 alone in adults with previously-treated metastatic pancreatic adenocarcinoma (eclipse study) Andrea Wang-Gillam, Vincent Picozzi, Todd Crocenzi, Michael Morse, Herbert Zeh, Robert Fine, Aimee Murphy, Justin Skoble, Edward Lemmens, Sandy Ferber, Allan Rosen, John...

OBJECTIVE Chronic rhinosinusitis (CRS) is a variable multifactorial disease. It can be divided into forms with nasal polyps (CRSwNP) and without (CRSsNP). Sinus and/or nasal polypectomy surgery are considered if maximal conservative treatment is insufficient. The predictive factors of the need of revision surgery comprise mostly the CRSwNP phenotype and are not fully understood. STUDY DESIGN ...

Chronic rhinosinusitis (CRS) is a clinical syndrome including several phenotypes and endotypes with differences in pathophysiology. CRS nasal polyposis (NP) the most severe phenotype associated significant influence on patients’ quality of life. Peculiarities endotype NP justify use aminocapronic acid (ACA) not only for preoperative preparation, but also as means pharmacotherapy. Aim: assessmen...

While succinct non-interactive zero-knowledge arguments of knowledge (zk-SNARKs) are widely studied, the question of what happens when the CRS has been subverted has received little attention. In ASIACRYPT 2016, Bellare, Fuchsbauer and Scafuro showed the first negative and positive results in this direction, proving also that it is impossible to achieve subversion soundness and (even non-subver...

BackgroundChronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings.ObjectiveThe aim of this study was to analyze the expression cytokines, prostaglandin (PG) synthases, and their receptors related pathogenesis CRS, especially those contributing nasal polyp (NP) formation.MethodsNPs uncinate tissue (UT) samples were collected from 90 patients who unde...

Cosmic-ray astrophysics has advanced rapidly in recent years, and its impact on other astronomical disciplines has broadened. Many new experiments measuring these particles, both directly in the atmosphere or space and indirectly via γ rays and synchrotron radiation, have widened the range and quality of the information available on their origin, propagation, and interactions. The impact of low...