Ventilator-associated pneumonia (VAP) is a common and serious problem that develops after more than 48 hours of mechanical ventilation. Improving the activity of immune system with vitamin D, and its consequent impact on prognostic biomarkers of VAP was studied in the current study. A randomized double blind placebo controlled clinical trial was designed. A total of 46 patients with VAP, who w...

Inappropriate antibiotic use for pulmonary infiltrates is common in the intensive care unit (ICU). We sought to devise an approach that would minimize unnecessary antibiotic use, recognizing that a gold standard for the diagnosis of nosocomial pneumonia does not exist. In a randomized trial, clinical pulmonary infection score (CPIS) (Pugin, J., R. Auckenthaler, N. Mili, J. P. Janssens, R. D. Le...

BACKGROUND Patients with nursing home acquired pneumonia (NHAP) present a distinct group of lower respiratory track infections with different risk factors, clinical presentation, and mortality rates. OBJECTIVES To evaluate the diagnostic value of clinical pulmonary infection score (CPIS), C-reactive protein, and procalcitonin and to compare the accuracy of pneumonia severity scores (confusion...

BACKGROUND Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in patients receiving this therapy. A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobu...

The utility of procalcitonin levels to improve the accuracy of clinical and microbiological parameters in diagnosing ventilator-associated pneumonia (VAP) was evaluated. Sequential measurement of procalcitonin and C-reactive protein levels and the calculation of the simplified Clinical Pulmonary Infection Scores (CPIS) were performed in 44 patients mechanically-ventilated for >48 h with neither...

Background: This study aimed to compare the effects of inhaled colistin and amikacin-fosfomycin combination in treatment ventilator-associated pneumonia (VAP) caused by extensively drug-resistant (XDR) Acinetobacter. clinical trial is first evaluate effect fosfomycin on VAP Iran. Methods: In this trial, 60 patients with Acinetobacter were divided into two groups 30 patients. The empirical regim...

BACKGROUND Differential diagnosis of patients with bilateral lung infiltrates remains a difficult problem for intensive care clinicians. Here we evaluate the diagnostic role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in bronchoalveolar lavage (BAL) specimens from patients with bilateral lung infiltrates. METHODS We conducted a prospective observational study on 80 p...

BACKGROUND A study was undertaken to assess the diagnostic value of different clinical criteria and the impact of microbiological testing on the accuracy of clinical diagnosis of suspected ventilator associated pneumonia (VAP). METHODS Twenty five deceased mechanically ventilated patients were studied prospectively. Immediately after death, multiple bilateral lung biopsy specimens (16 specime...

Background: Pneumonia is a common cause of morbidity and mortality in ICU patients under mechanical ventilation. In recent years the use herbal mouthwashes, due to antimicrobial effects fewer side effects, has been studied reducing incidence ventilator-associated pneumonia (VAP). this study, effect Persica mouthwash prevention VAP was compared with chlorhexidine. Methods: This study double-blin...