Mice singly housed and exposed to 50 C are almost as responsive as animals at 250 C in carrying out glyconeogenesis following a single injection of cortisone. An LD50 of endotoxin lowers liver glycogen about equally in mice housed at each of the two temperatures, but the dose for mice at 50 C is one one-hundredth the dose at 250 C. Cortisone given concurrently with the endotoxin prevents glycog...

A simple bone cyst of the proximal humeral metaphysis was found to cause growth disturbance with shortening and deformity in four patients. All had one pathological fracture. Three of them were treated with cortisone injections; the fourth patient, who presented an erosion of the physis, was treated with saline solution irrigation. Four hypotheses about the aetiology of growth arrest in the evo...

Rats were treated by intramuscular injection with cortisone acetate, 25 mg./day for 5 days. Small pieces of liver obtained from treated and normal animals were squashed on a microscope slide so as to obtain many areas only a single cell in thickness. After Feulgen staining to demonstrate DNA, optical density was measured using a projection technique. In both the normal and treated animals the n...

not succeed in obtaining significant glycogen production with rat-liver slices incubated with corticosteroids in vitro in the presence of glucose or pyruvate as substrates. The present results indicate first, that the well-marked in vitro action ofEschatin cannot be attributed to its content of cortisone or hydrocortisone and, secondly, that passage of cortisone through the body is necessary fo...

The pyruvate kinase (PK) activity of mouse liver increases after injection of endotoxin. It decreases in animals given cortisone alone and remains essentially unchanged in those given cortisone and endotoxin at the same time. CCl4 causes an increase in liver PK activity, but neither it nor endotoxin changes the activity of muscle PK. Addition of octonoate to liver homogenates inhibits the activ...

It was suggested in the most recent paper of this series (1) that protection by cortisone against the lethal effect of bacterial endotoxin is related to the ability of this and other glucocorticoids to induce de novo synthesis of certain liver enzymes (2-4). The injection of selected intermediates along the metabolic pathway initiated by the enzyme tryptophan pyrrolase increased survivorship fo...

THE unsatisfactory state of our knowledge regarding the effect of cortisone on capillary permeability has been discussed in a previous paper (Duke-Elder and Ashton, 1951). It was there noted that Leopold and others (1951), injecting fluorescein intravenously in rabbits and estimating its concentration in the aqueous humour, observed no delay in the appearance of the dye in the anterior chambers...

THE unsatisfactory state of our knowledge regarding the effect of cortisone on capillary permeability has been discussed in a previous paper (Duke-Elder and Ashton, 1951). It was there noted that Leopold and others (1951), injecting fluorescein intravenously in rabbits and estimating its concentration in the aqueous humour, observed no delay in the appearance of the dye in the anterior chambers...

The increase of sucrase activity in homogenates of jejunum and ileum of suckling rats after cortisone administration has been investigated. Serial tissue sections of villi and crypts were also assayed for sucrase activity and these results were compared with the migration of cells labelled with [(3)H]thymidine along the villus. By using a low dose of cortisone (0.5mg/day per 100g body wt.) it w...

Purpose. This study explored the effect of autologous blood injection (with ultrasound guidance) to the elbows of patients who had radiologically assessed degeneration of the origin of extensor carpi radialis brevis and failed cortisone injection/s to the lateral epicondylitis. Methods. This prospective longitudinal series involved preinjection assessment of pain, grip strength, and function, u...