BACKGROUND Epilepsy is the most common neurological problem that affects people with learning disabilities. The high seizure frequency, resistance to treatments, associated skills deficit and co-morbidities make the management of epilepsy particularly challenging for people with learning disabilities. The Books Beyond Words booklet for epilepsy uses images to help people with learning disabilit...

Epilepsy is one of the most common neurological disorders. as second burdensome neurologic disorder worldwide in terms disability-adjusted life years. Copper (Cu) involved a number enzymes with catalase and oxidase-type reactions. This study aimed to identify role serum copper etiology epilepsy its response treatment Methods: prospective case controlled that was conducted on patients attending ...

PURPOSE To evaluate sleep disturbances or sleep related events and their characteristics among patients with medically refractory epilepsy, compared to those with controlled epilepsy. METHODS In a prospective case-controlled study, patients of medically refractory and controlled epilepsy were recruited and history pertaining to epilepsy and sleep related events and Epworth sleepiness scores w...

Commentary Idiopathic generalized epilepsies (IGE) represent around 20% of all new-onset epilepsy and are controlled with various an-tiepileptic drugs in up to 80% of the cases. For the remaining 20% with intractable IGE, treatment options are limited. Most new AED clinical trials evaluate cohorts with partial epilepsy. The ketogenic diet has helped many children with catastrophic symptomatic g...

Lacosamide is a new-generation antiseizure medication that is approved for use as an adjunctive treatment and monotherapy in focal epilepsy. Its use in generalized epilepsy, however, has not been adequately evaluated in controlled trials. We report a 67-year-old woman who experienced new-onset myoclonic seizures after initiation of lacosamide. We presume that she had an undiagnosed generalized ...

Much attention in the literature has recently been paid to women's issues in epilepsy but most of the literature stops in the delivery room or at the first moment of suckling. Although it is commonly supposed that a woman who continues to have active epilepsy during the puerperium will pose a risk to her child, little assessment of how great a risk this is has been carried out. We present an au...

Posttraumatic epilepsy is a major source of disability following traumatic brain injury (TBI) and a common cause of medically-intractable epilepsy. Previous attempts to prevent the development of posttraumatic epilepsy with treatments administered immediately following TBI have failed. Recently, the mammalian target of rapamycin complex 1 (mTORC1) pathway has been implicated in mechanisms of ep...

BACKGROUND Concern has been expressed over UK epilepsy service standards but the most clinically effective model of care is unknown. OBJECTIVE To systematically review the current evidence on specialist epilepsy clinics compared to general neurology clinics and specialist epilepsy nurses compared to usual care. METHODS Medline, Psychlit, Embase, Healthplan, GEARS, BIDS ISI, UKCHHO, internat...

Significant advances have been made in the diagnosis and treatment of epilepsy over the past decade. With the advent of electroencephalographic video monitoring, physicians are now able to reliably differentiate epilepsy from other conditions that can mimic it, such as pseudoseizures. In addition, neuroimaging has changed the way treatment for difficult epilepsy is approached. As a result, the ...

Obsessive-compulsive disorder (OCD) has long been associated with epilepsy The link with temporal lobe (usually refractory) epilepsy (TLE) is particularly prominent Of TLE patients, 10% to 22% of patients may have OCD, often underdiagnosed in the outpatient clinic. Data on the links include case reports, case series, and controlled studies. Three larger, controlled studies in TLE patients, usin...