نتایج جستجو برای: colorectal carcinoma

تعداد نتایج: 454376  

Journal: :Oncology reports 2007
Masaru Saito Manabu Iwadate Masashi Higashimoto Koichiro Ono Yuji Takebayashi Seiichi Takenoshita

Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. PA acts as a second messenger in cell proliferation; therefore PLD is believed to play an important role in carcinogenesis. PLD activity has been reported to be elevated in human breast, gastric, renal cell and colorectal carcinomas, compared with adjacent non-neoplastic ti...

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Journal: :Molecular cancer research : MCR 2016
Jaclyn F Hechtman Ahmet Zehir Rona Yaeger Lu Wang Sumit Middha Tao Zheng David M Hyman David Solit Maria E Arcila Laetitia Borsu Jinru Shia Efsevia Vakiani Leonard Saltz Marc Ladanyi

UNLABELLED Targeted therapy for metastatic colorectal carcinoma consists of anti-EGFR therapy for patients with RAS/RAF wild-type tumors. However, the response rate remains low, suggesting the presence of alternative drivers possibly also representing potential therapeutic targets. We investigated receptor tyrosine kinase (RTK) alterations and MAP2K1 (MEK1) mutations in a large cohort of colore...

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Journal: :Tumori 2009
Antonio Russo Paola Sala Paola Alberici Isabella Gazzoli Paolo Radice Claudia Montefusco Margherita Torrini Cristina Mareni Mara Fornasarig Manuela Santarosa Alessandra Viel Piero Benatti Monica Pedroni Maurizio Ponz de Leon Emanuela Lucci-Cordisco Maurizio Genuardi Luca Messerini Vittoria Stigliano Alessandro Cama Maria Cristina Curia Laura de Lellis Stefano Signoroni Marco A Pierotti Lucio Bertario

AIMS AND BACKGROUND Colorectal carcinoma patients from hereditary non-polyposis colorectal cancer families are suggested to have a better prognosis than sporadic colorectal carcinoma cases. Since the majority of hereditary non-polyposis colorectal cancer-related colorectal carcinomas are characterized by microsatellite instability due to germline mutations in DNA mismatch repair genes, this is ...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Wei-Shu Wang Po-Min Chen Tzeon-Jye Chiou Jin-Hwang Liu Jen-Kou Lin Tzu-Chen Lin Huann-Sheng Wang Yeu Su

PURPOSE It has been shown that the R497K polymorphism of the epidermal growth factor receptor (EGFR) has attenuated functions in ligand binding, tyrosine kinase activation, and growth stimulation. Because the activation of EGFR results in an unfavorable prognosis of patients with colorectal carcinoma, a pilot study was conducted to assess the influence of this polymorphism on colorectal carcino...

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ژورنال: مجله علوم پزشکی رازی 1995
جلالی, سیدعلی,

More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...

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Journal: :Gaceta medica de Mexico 2016
Abril Reneé Arredondo-Valdez Laura Wence-Chavez Mónica Alejandra Rosales-Reynoso

The aim of this review is to present a general overview about the importance of micro RNAs (miRNAs) in colorectal carcinoma. First, we focused on the mechanisms whereby the miRNAs regulate the expression of target genes, and how an altered regulation of them is associated with several types of cancer, including colorectal carcinoma. Later, examples of some miRNAs that have been associated with ...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Sze Chuen Cesar Wong Siu Fong Elena Lo Moon Tong Cheung Kai On Enders Ng Chun Wah Tse Bo San Paul Lai King Chung Lee Y M Dennis Lo

PURPOSE Colorectal cancer is an important cause of cancer deaths. Here, we focused our investigation on the beta-catenin gene which is implicated in colorectal carcinogenesis and tested whether beta-catenin mRNA is detectable in the plasma of colorectal carcinoma and adenoma patients using quantitative reverse transcriptase-PCR. EXPERIMENTAL DESIGN Plasma beta-catenin mRNA was measured from 5...

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Journal: :International journal of epidemiology 1998
K Yamada S Araki M Tamura I Sakai Y Takahashi H Kashihara S Kono

BACKGROUND No one has previously examined the relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ. METHODS A case-control study was performed with 129 cases of colorectal carcinoma in situ and 258 matched controls among examinees undergoing a health check-up in Tokyo from January 1991 to March 1993. RESULTS There was a signific...

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2014
SHAOHUA CHEN YUQIAO DAI XUEMEI ZHANG DAOZHONG JIN XIAORONG LI YI ZHANG

Previously, microRNA-449a (miR-449a) has been shown to be involved in various types of cancer. However, its role in colorectal carcinoma remains unknown. The present study found that miR-449a expression was significantly increased in cultured colorectal carcinoma cells and cancer tissues obtained from 24 patients diagnosed with colorectal carcinoma, compared with the normal colorectal cells and...

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2010
Christopher Leung Francis A. Farraye

INTRODUCTION Patients with long-standing ulcerative colitis (UC) and Crohn’s disease of the colon are at an increased risk of developing colorectal neoplasia (dysplasia and colorectal carcinoma). The association of UC with colorectal carcinoma was first recognized in the 1920s [1]. In inflammatory bowel disease (IBD) the development of colorectal carcinoma (CRC) occurs through an inflammation-d...

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->