clostridium perfringens is a gram-positive, obligate anaerobic bacterium, which is widely distributed in the environment. c. perfringens is subdivided to 5 groups (types a to e), based on its four major toxin (alpha, beta, epsilon and iota). c. perfringens type b beta toxin causes inflammation and bloody necrotic enteritis. type b related enterotoxaemia is a major problem of veterinary sciences...

Clostridium butyricum is a kind of anaerobic bacteria, so de-aeration is extremely important during culture. In this paper, adding sodium thiosulfate and cysteine as well as mixed culture with Saccharomyces cerevisiae were adopted in de-aeration during Clostridium butyricum culture. The experimental results showed that the optimal dosage of sodium thiosulfate was 0.004g/mL, where the biomass of...

alpha toxin derived from clostridium perfringens was used for diagnosis of streptococcus agalactiae (st.agalactiae) by rapid and spot camp tests. the selected cl.perfringens strain was cultured in optimized conditions; the supernatant of culture was concentrated by ultra filter and purified by deae cellulose chromatography. the efficacy of both purified and crude α-toxins were examined by rapid...

tetanus is a disease caused by tetanus toxin, a potent inhibitor for the release of inhibitory neurotransmitter in the central nervous system that causes spastic paralysis. fragment c (52 kd) of this toxin is responsible for binding to the neuronal membrane. for this reason, and also its non toxigenic and immunogenic nature, this fragment might be ideal for new vaccine development. presently, w...

Clostridioides (Clostridium) difficile (C. difficile) is a gram-positive bacterium that infects the large intestine. The number of clostridium infections has increased in recent years due to multiple risk factors including frequent use antibiotics and proton pump inhibitors. virulence C. comes from its production toxins. Treatment for infection includes antibiotics, monoclonal antibodies, or fe...

Background: Metronidazole resistant clostridium difficile is one of significant pathogens in Iran. It is one of the WHO-declared microbial resistance emergencies. Prevalence of metronidazole resistant clostridium difficile is rising. The aim of this study was to detect prevalence of metronidazole-resistant clostridium difficile using meta-analysis in Iran. Methods: This study was conducted as ...

TO THE EDITOR—Several of us have served in the military, and the recent cover of Clinical Infectious Diseases (The Treatment of a Gangrenous Leg, woodcut, 16th century) [1] intrigued us. We wondered how much aggressive surgical debridement and effective antibiotic regimens have improved survival of patients with gas gangrene since that time? Clostridialmyonecrosis (gas gangrene), a monomicrobia...

The aim of this study was to identify different Clostridium spp. isolated from currency notes from the Ha'il region of Saudi Arabia in September 2014 using MALDI-TOF-MS. Clostridium spp. were identified by Bruker MALDI-TOF-MS and compared with VITEK 2. The confirmation of the presence of different Clostridium spp. was performed by determining the sequence of the 16S ribosomal RNA gene. In this ...