background   lipoprotein lipase activity can be increased by clofibrate. clofibrate is used to reduce serum triglyceride level in adults. the aim of this study was to determine the effect of clofibrate on serum triglyceride and cholesterol level after administration of intravenous lipid in very low birth weight neonates. method in a randomized double blind placebo – controlled study, 60 very lo...

background: clofibrate is an effective anti lipid agent that induces glucuronyltransferase could increase bilirubin conjugation. the aim of this study was to evaluate effect of clofibrate on neonatal physiologic jaundice. methods: randomized clinical trial sampling method used and 60 healthy term neonates which were admitted in imam reza hospital of kermanshah-iran because of indirect hyperbili...

The Treatment of Cerebrovascular Disease With Clofibrate • A cooperative study in 20 Veterans Administration hospitals investigated the effect of clofibrate on morbidity and mortality due to atherosclerotic vascular disease in men with either an established cerebral infarction or transient cerebrovascular ischemic attacks (TIA). Follow-up observations were made for up to 4.5 years in 532 patien...

The Treatment of Cerebrovascular Disease With Clofibrate • A cooperative study in 20 Veterans Administration hospitals investigated the effect of clofibrate on morbidity and mortality due to atherosclerotic vascular disease in men with either an established cerebral infarction or transient cerebrovascular ischemic attacks (TIA). Follow-up observations were made for up to 4.5 years in 532 patien...

OBJECTIVE This study was designed to determine the effect of clofibrate on neonatal uncomplicated jaundice treated with home phototherapy. METHODS This clinical trial study was performed on 60 newborns with jaundice that received home phototherapy. Inclusion criteria were body weight between 2500 to 4000 gr, breastfed, total serum bilirubin (TSB) between 14 to 20 mg/dl, aged over 72 hours. Th...

Platelet function was evaluated in 29 patients with familial hyperbetalipoproteinemia; 17 were untreated and 12 were receiving clofibrate (Atromid-S). In comparison with 26 normal subjects, the untreated patients aggregated in response to 1/3 the concentration of adenosine diphosphate (ADP), '/25 the concentration of epinephrine, and '/4 the concentration of collagen. Treatment with clofibrate,...

The Treatment of Cerebrovascular Disease With Clofibrate • A cooperative study in 20 Veterans Administration hospitals investigated the effect of clofibrate on morbidity and mortality due to atherosclerotic vascular disease in men with either an established cerebral infarction or transient cerebrovascular ischemic attacks (TIA). Follow-up observations were made for up to 4.5 years in 532 patien...

Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (PP) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans. Their oncogenicity is usually ascribed to mitogenic or antiapoptotic action. However, we have reported that clofibrate can trigger fast and extensive apoptosis in rodent and human tumor cell lines. The present study exami...

The Treatment of Cerebrovascular Disease With Clofibrate • A cooperative study in 20 Veterans Administration hospitals investigated the effect of clofibrate on morbidity and mortality due to atherosclerotic vascular disease in men with either an established cerebral infarction or transient cerebrovascular ischemic attacks (TIA). Follow-up observations were made for up to 4.5 years in 532 patien...

Chronic clofibrate intake, on occasion, results in a muscular syndrome in man. We have investigated the effects of chronic clofibrate administration in rats on the electrical activity of a skeletal muscle (gastrocnemius), its composition, and its oxidation of palmitate and glucose. These effects have been compared with those in the liver. Clofibrate administration altered electromyographic patt...