A woman aged 23 years, with no past medical history of interest, was seen for the appearance a week earlier of pruritic skin lesions in the area of a tattoo created on the dorsum of her right foot 6 months earlier (Fig. 1). The patient denied taking any new medication or applying any topical products. There were no lesions on the rest of her skin or mucosas or lesions of the skin appendages. De...

Table I. Patients’ own opinion regarding eYcacy after 12 Sir, months Calcipotriol, a vitamin D derivative, has proven to be eVective in the treatment of nail psoriasis (1–4). The Hands (n= 48) Feet (n= 53) purpose of this open study was to evaluate the eYcacy n (%) n (%) and safety of the combined treatment of nail psoriasis Poor 3 (6.2) 6 (11.3 ) with calcipotriol cream and clobetasol propiona...

Study sample The sample size was not determined in the planning phase of the study, and power calculations were not performed retrospectively. Initially, 7 women and 25 men (mean age 49 years) were enrolled in the study, all being residents of the San Francisco Bay area. Three patients were excluded and a justification for their exclusion was provided. The number of patients allocated to the tw...

OBJECTIVE We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions. STUDY DESIGN Over a 48-week period, we evaluated the evolution of pain, ulcerations, atrophy, and interference of the disease in the patient's daily life, classifying the response as complete (100% remission/recovery), excell...

BACKGROUND Lichen sclerosus is a chronic cutaneous disorder with a predilection for the vulva. Lichen sclerosus affects more than one in 900 girls. Superpotent corticosteroids like clobetasol propionate are the most effective treatment for vulvar lichen sclerosus. However, recurrence after stopping steroids is very high. As repeated courses of corticosteroids are frequently needed, there are co...

PURPOSE We report our experience with the use of a topical steroid, 0.05% clobetasol propionate, for the treatment of phimosis with clinical complications. MATERIALS AND METHODS This was a retrospective analysis of the clinical outcomes of all patients presenting with phimosis to a single institution during the time period from October 2008 to May 2012. A total of 88 patients who had a Kikiro...

Clobetasol propionate (CP) is a potent topical corticosteroid that causes several cutaneous and systemic side effects. In the present work, CP was encapsulated in nanostructured lipid carriers (NLCs) to increase drug retention in the outer skin layers and improve the safety of topical therapy. NLCs were prepared using a microemulsion technique with a mixture of lecithin, taurodeoxycholate, stea...

OBJECTIVE We sought to describe the response of patients with severe erosive gingival lesions to treatment with clobetasol propionate in Orabase paste administered in trays. The adverse effects were also recorded. STUDY DESIGN A descriptive pretest/posttest clinical study with no control group (33 patients total) was developed. All patients received repeated applications of 0.05% clobetasol p...

BACKGROUND Desquamative gingivitis (DG) is a clinical condition characterized by red, painful, glazed, and friable gingiva, which might be a manifestation of some autoimmune mucocutaneous diseases. The time from the development of initial signs of DG to diagnosis can vary from months to years. Based on a literature search, no data concerning patients with DG without signs of autoimmune disease ...

The physical and chemical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, the objective of this work was to study the stability of clobetasol propionate (CP) in a nanoemulsion. The nanoemulsion formulation containing CP was prepared by the spontaneous emulsification method. For the formulation of the nanoemulsion, Safsol, Tween 20, ethanol, and...