BACKGROUND Although accumulating data has implicated a role for the Apelinergic system in cirrhosis, the role of Apelin during different stages of fibrogenesis has not been clarified, whereas no studies have been conducted on its expression in human hepatocellular carcinoma (HCC). This study aimed to elucidate its role in hepatic remodelling and carcinogenesis. METHODS Immunolocalization of A...

cirrhosis is associated with hyperdynamic circulation, manifesting as increased cardiac output and decreased systemic vascular resistance. the aim of this study was to investigate the effect of cirrhosis on heart apoptosis and involvement of nitric oxide (no) and oxidative stress in the possible altered apoptosis of cirrhotic hearts. twenty-eight days after bile duct ligation, heart tissues wer...

Hepatocellular carcinoma (HCC) is one of the leading causes of neoplastic morbidity and mortality worldwide, and despite recent treatment advances, the prognosis remains dismal, with a 5-year mortality rate of 85%. The surveillance and timely diagnosis is therefore of crucial importance in order to improve survival rates and alleviate the health burden imposed by the HCC. Previously, HCC diagno...

BACKGROUND Hepatocellular carcinoma (HCC) is associated with high mortality. Patients with hepatitis B or C viral cirrhosis have an increased risk of developing HCC. Ultrasound is the most widely used screening method, and is recommended by many guidelines. OBJECTIVE To study the sonographic findings ofHCC detected in ultrasound surveillance of cirrhotic patients. MATERIAL AND METHOD Retros...

Introduction T1-weighted (T1W) hyperintense nodules against a background of cirrhosis are diagnostically challenging in clinical practice. Differentiation of T1W hyperintense nodule into benign or malignant nodule is a challenging task without histopathological examination in patient with cirrhotic liver. Since hepatic resection or transplantation is the most effective treatment for HCC if the ...

The incidence of hepatocellular carcinoma (HCC) is rising worldwide. Although the best chance for long-term survival is early detection, screening high-risk populations to detect HCC when it is most treatable still has only limited success. Once detected within the cirrhotic liver, many observations still defy correct characterization, due in part to a history of nonstandarized nomenclature and...

BACKGROUND Imaging of the liver is a key component in the detection, diagnosis, management, and follow-up of patients with hepatocellular carcinoma. METHODS The author uses his own experience as well as a review of pertinent literature to describe the capabilities and the limitations of the principal currently available imaging techniques for the liver. RESULTS Ultrasound is widely availabl...

BACKGROUND & AIMS To compare treatment failure and survival associated with ultrasound-guided radiofrequency ablation (RFA) and trans-arterial chemoembolization (TACE) for early-stage HCC in Child-Pugh A cirrhosis patients. METHODS 122 cirrhotic patients (RFA: 61; TACE: 61) were well matched according to cirrhosis severity; tumor size and serum alpha-fetoprotein. TACE was performed in case of...

Hepatocellular adenoma is a benign neoplasm that almost always occurs in a histologically normal liver. We report the finding of a hepatocellular adenoma in the cirrhotic liver of a 56year-old female patient. A hypervascular nodule was detected by computed tomography (CT) scan and magnetic resonance imaging (MRI) conducted as part of a pre-transplant evaluation. The patient subsequently underwe...